{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:38:19Z","timestamp":1753882699325,"version":"3.41.2"},"reference-count":13,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p> VIPoma, a neuroendocrine tumour mostly occurring in the human pancreas and producing high levels of vasoactive intestinal peptide, is a rare disease that presents with a wide spectrum of symptoms, including intense diarrhoea, hypokalaemia, and cardiac complications, with life-threatening consequences. In most cases, metastatic lesions are present at VIPoma diagnosis. Treatment options include symptomatic therapy, chemotherapy, radiation and surgery. Due to its low incidence, there are no evidence-based therapy recommendations to date. Here, we present a case of a 39-year-old woman with severe symptoms due to VIPoma of the pancreas with diffuse hepatic metastasis, who underwent simultaneous resection of the primary tumour, extensive liver resection and radiofrequency ablation. The patient was released in good health and was recurrence-free during 12\u2009months surveillance. According to the existing literature and our own experience, surgical procedures appear to be the most promising therapy option for cases with diffuse hepatic metastasis, offering patients relief from their symptoms and (chemo)therapy-free time. <\/jats:p>","DOI":"10.1177\/17562848211051132","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T07:26:38Z","timestamp":1638861998000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Surgical treatment of metastatic VIPoma: a case report"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4270-5706","authenticated-orcid":false,"given":"Azadeh","family":"Azizian","sequence":"first","affiliation":[{"name":"Department of General, Visceral, and Pediatric Surgery, University Medical Center Goettingen, Goettingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Gastrointestinal Oncology, University Medical Center Goettingen, Goettingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amelie","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Endocrinology, Diabetology and General Medicine, Klinikum Kassel GmbH, Kassel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Schuppert","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Endocrinology, Diabetology and General Medicine, Klinikum Kassel GmbH, Kassel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Seif Amir Hosseini","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Medical Center Goettingen, Goettingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Kitz","sequence":"additional","affiliation":[{"name":"Institute of Pathology, University Medical Center Goettingen, Goettingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Ghadimi","sequence":"additional","affiliation":[{"name":"Department of General, Visceral, and Pediatric Surgery, University Medical Center Goettingen, Robert-Koch-Stra\u00dfe 40, 37077 Goettingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,12,6]]},"reference":[{"key":"bibr1-17562848211051132","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-123-31488"},{"key":"bibr2-17562848211051132","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.18039.1"},{"key":"bibr3-17562848211051132","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(58)90075-5"},{"key":"bibr4-17562848211051132","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2017.04.026"},{"key":"bibr5-17562848211051132","first-page":"395","volume":"449","author":"Rindi G","year":"2006","journal-title":"et al"},{"key":"bibr6-17562848211051132","first-page":"2273","volume":"80","author":"Perry RR","year":"1995","journal-title":"J Clin Endocrinol 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