{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T22:15:15Z","timestamp":1773958515801,"version":"3.50.1"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Jinan Clinical Medical Science and Technology Innovation Program","award":["202019101"],"award-info":[{"award-number":["202019101"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:title>Introduction:<\/jats:title><jats:p> Linaclotide, a guanylate cyclase C agonist that improves the symptoms of irritable bowel syndrome with predominant constipation (IBS-C), has been recently approved for IBS-C treatment. This study aimed to report real-world data on linaclotide treatment in China. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> This was a prospective multicentre study of the effectiveness of linaclotide treatment in patients with IBS-C from 10 primary medical institutions. Changes in defecation, abdominal symptoms, the IBS symptom severity scale (IBS-SSS), IBS quality of life questionnaire (IBS-QOL), Zung Self-Rating Anxiety Scale and Self-Rating Depression Scale in patients were evaluated to determine the drug\u2019s clinical efficacy and safety. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> We enrolled 97 patients (mean age: 52.39\u2009\u00b1\u200913.99\u2009years), 55 of whom were women (56.7%). In terms of efficacy, the number of the patients\u2019 defecation per week and Bristol stool form scale scores significantly increased at week 4 and week 12 compared with the values at the baseline. The baseline average IBS-SSS score was 211.01\u2009\u00b1\u200981.23. Of the patients, 24 had severe IBS-C, and their IBS-SSS scores at week 4 (51.81\u2009\u00b1\u200954.42) and week 12 (9.3\u2009\u00b1\u200930.39) significantly decreased and showed a pronounced improvement. The IBS-QOL total scores at week 4 and week 12 gradually decreased compared with that at the baseline and the QOL significantly improved. Treatment satisfaction rate was 79.3% in week 4 and 100% in week 12, showing a gradually increased satisfaction and significant differences. However, 11 cases (11.3%) had diarrhoea. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Linaclotide has proved to be a safe and effective drug to improve IBS-C symptoms and severity. <\/jats:p><\/jats:sec>","DOI":"10.1177\/17562848221092596","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T07:35:36Z","timestamp":1651217736000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Linaclotide for treating patients with irritable bowel syndrome with predominant constipation: a multicentre study of real-world data in China"],"prefix":"10.1177","volume":"15","author":[{"given":"Lan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, The Second Hospital of Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second Hospital of Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second Hospital of Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second Hospital of Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaojun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Sunshine Union Hospital, Weifang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojun","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Fangzi District People\u2019s Hospital, Weifang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Wendeng District People\u2019s Hospital, Weihai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Rongcheng Hospital of Traditional Chinese Medicine, Weihai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enbin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Rongcheng People\u2019s Hospital, Weihai, 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