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Although acid suppression represents the mainstay of treatment in adolescents, it is not devoid of adverse events, especially in the long-term. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives:<\/jats:title><jats:p> In this investigation we explored a new therapeutic avenue in GERD, that is esophageal mucosal protection. <\/jats:p><\/jats:sec><jats:sec><jats:title>Design:<\/jats:title><jats:p> To this end, we performed an investigator-initiated, retrospective study to evaluate the efficacy and safety of a short-term treatment with Esoxx\u2122 medical device in 25 adolescents with GERD-related symptoms. This mucoadhesive formulation contains two natural mucopolysaccharides (sodium hyaluronate and chondroitin sulphate) and adheres to the esophageal mucosa, exerting a protective effect against refluxed gastric contents and allowing mucosal healing. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Heartburn, epigastric burning and post-prandial regurgitation were scored with a pain VAS scale and re-evaluated after 3-week treatment with Esoxx (one stick post-prandially, three times daily). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> All patients completed the treatment without adverse effects and with good tolerability and compliance. All the three major symptoms significantly (p&lt;0.001) improved after treatment. No patient required additional investigation (i.e. upper Gastrointestinal endoscopy) or medication (i.e. antisecretory drugs). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> The results of this pilot study suggest that esophageal mucosal protection is a promising therapeutic avenue for GERD also in children. Provided, these data be confirmed by a large, randomized clinical trial, this medical device can enter our therapeutic armamentarium against this challenging disease. <\/jats:p><\/jats:sec>","DOI":"10.1177\/17562848221115319","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T12:55:43Z","timestamp":1660740943000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Pharmacologic treatment of GERD in adolescents: Is esophageal mucosal protection an option?"],"prefix":"10.1177","volume":"15","author":[{"given":"Claudio","family":"Romano","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology and Cystic Fibrosis Unit, Department of Human Pathology in Adulthood and Childhood \u201cG. 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