{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:35:53Z","timestamp":1753882553389,"version":"3.41.2"},"reference-count":41,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> The Coronavirus Disease 2019 (COVID-19) pandemic poses a massive crisis to global public health. Gastrointestinal (GI) symptoms are increasingly reported in COVID-19. The characteristics of laboratory findings of COVID-19 are critical for clinical diagnosis and treatment. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives:<\/jats:title><jats:p> The study aimed to summarize laboratory features in COVID-19 with GI symptoms and non-GI symptoms. <\/jats:p><\/jats:sec><jats:sec><jats:title>Design:<\/jats:title><jats:p> This study was a systematic review and meta-analysis. Electronic literature searches were conducted for studies that included patients infected COVID-19 with GI symptoms and non-GI symptoms. GI symptoms included diarrhea, abdominal pain, nausea and vomiting, and anorexia. This study used a random-effects model to assess pooled data. <\/jats:p><\/jats:sec><jats:sec><jats:title>Data sources and methods:<\/jats:title><jats:p> We systematically searched PubMed, Embase, Cochrane, Web of Science for studies through 31 October 2021, with no language restrictions. We used the following search terms: \u2018COVID-19\u2019 OR \u20182019-nCoV\u2019 OR \u2018SARS-CoV-2\u2019 OR \u2018coronavirus 2019\u2019 OR \u2018severe acute respiratory syndrome coronavirus 2\u2019 OR \u2018coronavirus\u2019 OR \u2018novel coronavirus\u2019 OR \u2018nCoV\u2019 AND \u2018gastrointestinal symptoms\u2019 OR \u2018digestive symptoms\u2019 AND \u2018clinical feature\u2019 OR \u2018clinical characteristics.\u2019 Data mostly originated from Chinese and American studies. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Of 796 identified studies, 14 were eligible and were included in our analysis ( N\u2009=\u20098396 participants). Meta-analysis showed that GI symptoms group had an elevated alanine aminotransferase (ALT) [pooled mean difference (MD), 4.5\u2009U\/L; 95% confidence interval, [0.45, 8.55]; p\u2009=\u20090.03; I<jats:sup>2<\/jats:sup>\u2009=\u200987%]. No publication bias was detected by Begg\u2019s and Egger\u2019s regression test ( p\u2009=\u20090.130). COVID-19 with the GI symptoms also showed a trend toward decreased white blood cell count, lymphopenia, neutrophilia, thrombocytopenia and elevated total bilirubin. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> GI symptoms are common in COVID-19. No significant differences were found in most laboratory indicators except elevated ALT. <\/jats:p><\/jats:sec><jats:sec><jats:title>Registration:<\/jats:title><jats:p> CRD42020209039 (PROSPERO). <\/jats:p><\/jats:sec>","DOI":"10.1177\/17562848221116264","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T11:55:18Z","timestamp":1661169318000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of laboratory characteristics of gastrointestinal symptoms and nongastrointestinal symptoms in patients infected with COVID-19: a systematic review and meta-analysis"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8197-7320","authenticated-orcid":false,"given":"Rui","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Beijing Chaoyang Hospital, Capital Medical University, Beijing, PR 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