{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T14:15:43Z","timestamp":1769004943834,"version":"3.49.0"},"reference-count":30,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Fully covered intraductal self-expanding metal stents (IDSEMS) have been well described in the management of post-liver transplant (LT) anastomotic strictures (ASs). Their antimigration waists and intraductal nature make them suited for deployment across the biliary anastomosis. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives:<\/jats:title><jats:p> We conducted a multicentre study to analyse their use and efficacy in the management of AS. <\/jats:p><\/jats:sec><jats:sec><jats:title>Design:<\/jats:title><jats:p> This was a retrospective, multicentre observational study across nine tertiary centres in the United Kingdom. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Consecutive patients who underwent endoscopic retrograde cholangiopancreatography with IDSEMS insertion were analysed retrospectively. Recorded variables included patient demographics, procedural characteristics, response to therapy and follow-up data. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> In all, 162 patients (100 males, 62%) underwent 176 episodes of IDSEMS insertion for AS. Aetiology of liver disease in this cohort included hepatocellular carcinoma ( n\u2009=\u200935, 22%), followed by alcohol-related liver disease ( n\u2009=\u200929, 18%), non-alcoholic steatohepatitis ( n\u2009=\u200920, 12%), primary biliary cholangitis ( n\u2009=\u200915, 9%), acute liver failure ( n\u2009=\u200913, 8%), viral hepatitis ( n\u2009=\u200913, 8%) and autoimmune hepatitis ( n\u2009=\u200912, 7%). Early AS occurred in 25 (15%) cases, delayed in 32 (20%) cases and late in 95 (59%) cases. Age at transplant was 54\u2009years (range, 12\u201374), and stent duration was 15\u2009weeks (range, 3\u2009days\u201378\u2009weeks). In total, 131 (81%) had complete resolution of stricture at endoscopic re-evaluation. Stricture recurrence was observed in 13 (10%) cases, with a median of 19\u2009weeks (range, 4\u201388\u2009weeks) after stent removal. At removal, there were 21 (12%) adverse events, 5 (3%) episodes of cholangitis and 2 (1%) of pancreatitis. In 11 (6%) cases, the removal wires unravelled, and 3 (2%) stents migrated. All were removed endoscopically. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> IDSEMS appears to be safe and highly efficacious in the management of post-LT AS, with low rates of AS recurrence. <\/jats:p><\/jats:sec>","DOI":"10.1177\/17562848221122473","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T09:40:03Z","timestamp":1664185203000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Intraductal fully covered self-expanding metal stents in the management of post-liver transplant anastomotic strictures: a UK wide experience"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4034-7570","authenticated-orcid":false,"given":"Wafaa","family":"Ahmed","sequence":"first","affiliation":[{"name":"Institute for Liver Studies, King\u2019s College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dave","family":"Kyle","sequence":"additional","affiliation":[{"name":"Institute of Liver Studies, King\u2019s College Hospital NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amardeep","family":"Khanna","sequence":"additional","affiliation":[{"name":"Institute of Liver Studies, King\u2019s College Hospital NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Devlin","sequence":"additional","affiliation":[{"name":"Institute of Liver Studies, King\u2019s College Hospital NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Reffitt","sequence":"additional","affiliation":[{"name":"Institute of Liver Studies, King\u2019s College Hospital NHS Foundation Trust, London, 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Addenbrooke\u2019s Hospital, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Gelson","sequence":"additional","affiliation":[{"name":"Cambridge Liver Unit, Addenbrooke\u2019s Hospital, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manu","family":"Nayar","sequence":"additional","affiliation":[{"name":"Freeman Hospital, Newcastle upon Tyne, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haider","family":"Khan","sequence":"additional","affiliation":[{"name":"Southwest Liver Unit and Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Cramp","sequence":"additional","affiliation":[{"name":"Southwest Liver Unit and Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Potts","sequence":"additional","affiliation":[{"name":"Royal Free Sheila Sherlock Liver Centre, Royal Free Hospital and UCL Institute of Liver and Digestive Health, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waleed","family":"Fateen","sequence":"additional","affiliation":[{"name":"Royal Free Sheila Sherlock Liver Centre, Royal Free Hospital and UCL Institute of Liver and Digestive Health, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamish","family":"Miller","sequence":"additional","affiliation":[{"name":"Royal Free Sheila Sherlock Liver Centre, Royal Free Hospital and UCL Institute of Liver and Digestive Health, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bharat","family":"Paranandi","sequence":"additional","affiliation":[{"name":"Leeds Teaching Hospitals NHS Trust, Leeds, 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