{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T17:13:28Z","timestamp":1782494008829,"version":"3.54.5"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Pregabalin is worldwidely licensed for the treatment of a variety of pain syndromes and supposed to be a potential candidate for the centrally mediated abdominal pain syndrome (CAPS). <\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives:<\/jats:title><jats:p> To investigate the efficacy of pregabalin on nociceptive and emotional symptoms in CAPS patients. <\/jats:p><\/jats:sec><jats:sec><jats:title>Design:<\/jats:title><jats:p> This is an open-label randomized controlled trial. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> CAPS patients were randomized to receive pregabalin 75\u2009mg (P group), pinaverium bromide 50\u2009mg (PB group), or pregabalin combined pinaverium bromide regimen (P\u2009+\u2009PB group) three times daily for 4\u2009weeks. Questionnaires were completed biweekly. The primary outcomes were defined as the average abdominal pain scores of severity and frequency at weeks 2 and 4. Secondary outcomes included the reduction in abdominal pain scores, Somatic Self-rating Scale (SSS), Patient Health Questionnaire-15 (PHQ-15), and Generalized Anxiety Disorder Scale 7 (GAD-7) scales obtained at the end of trial to the baseline. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Totally, 102 eligible patients were recruited and randomized. The mean severity scores of abdominal pain were 1.39\u2009\u00b1\u20091.28, 0.97\u2009\u00b1\u20091.43 versus 2.91\u2009\u00b1\u20091.44 ( p\u2009&lt;\u20090.0001) in P or PB\u2009+\u2009P group versus PB group at week 2 and were 0.90\u2009\u00b1\u20091.21, 1.28\u2009\u00b1\u20091.87 versus 2.74\u2009\u00b1\u20091.75 ( p\u2009&lt;\u20090.0001) at week 4. The mean frequency scores were 2.55\u2009\u00b1\u20092.55, 2.03\u2009\u00b1\u20092.80 versus 5.12\u2009\u00b1\u20092.09( p\u2009&lt;\u20090.0001) in P or PB\u2009+\u2009P group versus PB group at week 2 and were 1.72\u2009\u00b1\u20092.46, 2.00\u2009\u00b1\u20092.90 versus 4.55\u2009\u00b1\u20092.55 ( p\u2009&lt;\u20090.0001) at week 4. When comparing the changes in SSS, PHQ-15, and GAD-7 scores, patients accepting pregabalin or pregabalin combination regimen reported a more decrease than pinaverium bromide recipients ( p\u2009=\u20090.0002, p\u2009=\u20090.0002, and p\u2009=\u20090.0033). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> This trial suggests that pregabalin may be beneficial for CAPS abdominal pain and concomitant somatic or anxiety symptoms. <\/jats:p><\/jats:sec><jats:sec><jats:title>Registration:<\/jats:title><jats:p> www.chictr.org.cn (ChiCTR1900028026) <\/jats:p><\/jats:sec>","DOI":"10.1177\/17562848231152334","type":"journal-article","created":{"date-parts":[[2023,3,4]],"date-time":"2023-03-04T06:56:20Z","timestamp":1677912980000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Randomized clinical trial: the effects of pregabalin for centrally mediated abdominal pain 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