{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:35:58Z","timestamp":1753882558958,"version":"3.41.2"},"reference-count":48,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Chromoendoscopy is preferred over high-definition white light endoscopy (HDWLE) for dysplasia surveillance in inflammatory bowel disease (IBD) patients, but is more time-consuming to perform and real-world evidence is limited. The prevalence of sessile serrated lesions (SSLs) in IBD patients is also unknown. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objective:<\/jats:title><jats:p> To determine the yield of polypoid and non-polypoid dysplasia and SSLs in IBD patients undergoing dysplasia surveillance and the associations for these lesions. <\/jats:p><\/jats:sec><jats:sec><jats:title>Design:<\/jats:title><jats:p> A retrospective cohort study from a tertiary IBD centre. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> A keyword search of the colonoscopy reporting system was performed. IBD patients with colonic disease that underwent colonoscopy for surveillance between 1 February 2015 and 1 February 2018 were included. Clinical, endoscopic and histopathological outcomes were extracted for the analysis. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Of 2114 patients identified, 276 eligible colonoscopies in 126 patients were analysed. The median age at colonoscopy was 51\u2009years (interquartile range: 42\u201358\u2009years). 71\/126 (56%) of colonoscopies were performed in male patients, with 57\/126 (45%) having ulcerative colitis, 68\/126 (54%) Crohn\u2019s colitis and 1\/126 (0.79%) IBD-unspecified. The prevalence for any neoplasia was 75\/276 (27%). The prevalence for all serrated lesions was 43\/276 (16%). Increased age was a risk factor for finding a neoplastic lesion on both univariate and multivariate analyses. Chromoendoscopy was associated with twice the odds of finding a neoplastic lesion (odds ratio: 1.99, 95% confidence interval: 1.13\u20133.51, p\u2009=\u20090.02), on multivariate analysis. No factor was associated with an increased risk of finding a serrated lesion. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Significant neoplastic lesions and serrated lesions were detected in 27% and 16% of colonoscopies performed in IBD patients, respectively, with the highest yield in older patients. Chromoendoscopy significantly increased neoplasia yield compared to HDWLE and still has a robust utility in this pragmatic real-world study. <\/jats:p><\/jats:sec>","DOI":"10.1177\/17562848231167280","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T06:19:18Z","timestamp":1683181158000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The yield of dysplasia and serrated lesions in a single-centre tertiary inflammatory bowel disease cohort"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7275-7051","authenticated-orcid":false,"given":"Fiona","family":"Yeaman","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Fiona Stanley Hospital, Murdoch, WA, Australia"},{"name":"Department of Internal Medicine, UWA Medical School, University of Western Australia, Perth, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2816-3533","authenticated-orcid":false,"given":"Lena","family":"Thin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, UWA Medical School, University of Western Australia"},{"name":"Department of Gastroenterology, Fiona Stanley Hospital, 11 Robin Warren Drive, Perth, WA 6009, Murdoch, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,5,3]]},"reference":[{"key":"bibr1-17562848231167280","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91889-I"},{"key":"bibr2-17562848231167280","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010215)91:4<854::AID-CNCR1073>3.0.CO;2-Z"},{"key":"bibr3-17562848231167280","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.01.010"},{"key":"bibr4-17562848231167280","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjx008"},{"key":"bibr5-17562848231167280","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.11.310"},{"key":"bibr6-17562848231167280","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2020.04.068"},{"key":"bibr7-17562848231167280","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(11)61671-5"},{"key":"bibr8-17562848231167280","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.161"},{"key":"bibr9-17562848231167280","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.3767"},{"key":"bibr10-17562848231167280","doi-asserted-by":"publisher","DOI":"10.4132\/jptm.2020.04.15"},{"key":"bibr11-17562848231167280","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12774"},{"key":"bibr12-17562848231167280","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5490803"},{"key":"bibr13-17562848231167280","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/386540"},{"key":"bibr14-17562848231167280","doi-asserted-by":"publisher","DOI":"10.1111\/his.14298"},{"key":"bibr15-17562848231167280","doi-asserted-by":"publisher","DOI":"10.4132\/jptm.2021.02.17"},{"key":"bibr16-17562848231167280","first-page":"19","volume":"14","author":"Parian AM","year":"2018","journal-title":"Gastroenterol Hepatol"},{"key":"bibr17-17562848231167280","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-022-07485-w"},{"key":"bibr18-17562848231167280","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309861.28"},{"key":"bibr19-17562848231167280","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2014.12.009"},{"key":"bibr20-17562848231167280","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv141"},{"key":"bibr21-17562848231167280","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.12.037"},{"key":"bibr22-17562848231167280","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.suppl_5.v10"},{"key":"bibr23-17562848231167280","unstructured":"Cancer Council Australia Surveillance Colonoscopy Guidelines Working Party. 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