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Strategies are needed to overcome challenges in study designs and conducting clinical trials and provide impetus to the field of drug development in the landscape of ALD and alcoholic hepatitis. Management of ALD is complex and should include therapies to achieve and maintain alcohol abstinence, preferably delivered by a multidisciplinary team. Although associated with clear mortality benefit in select patients, the use of early liver transplantation still requires refinement to create uniformity in selection protocols across transplant centers. There is also a need for reliable noninvasive biomarkers for prognostication. Last but not the least, strategies are urgently needed to implement integrated multidisciplinary care models for treating the dual pathology of alcohol use disorder and of liver disease for improving the long-term outcomes of patients with ALD. <\/jats:p>","DOI":"10.1177\/17562848231170946","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T19:30:06Z","timestamp":1683747006000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Therapeutic targets in alcohol-associated liver disease: progress and challenges"],"prefix":"10.1177","volume":"16","author":[{"given":"Ayooluwatomiwa Deborah","family":"Adekunle","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, St. Luke\u2019s Hospital, Chesterfield, Missouri, USA"},{"name":"Division of Hepatology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"},{"name":"Division of Transplant Hepatology, University of South Dakota Sanford Medical School, Sioux Falls, SD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeyinka","family":"Adejumo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, St. Luke\u2019s Hospital, Chesterfield, Missouri, USA"},{"name":"Division of Hepatology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"},{"name":"Division of Transplant Hepatology, University of South Dakota Sanford Medical School, Sioux Falls, SD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1207-3998","authenticated-orcid":false,"given":"Ashwani K.","family":"Singal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, St. Luke\u2019s Hospital, Chesterfield, Missouri, USA"},{"name":"Division of Hepatology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"},{"name":"Division of Transplant Hepatology, University of South Dakota Sanford Medical School, 1325 S. 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