{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T18:14:50Z","timestamp":1778091290267,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006484","name":"Vifor Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Iron deficiency anemia (IDA) is a common extraintestinal manifestation of inflammatory bowel disease (IBD), affecting around one-third of patients. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objective:<\/jats:title><jats:p> To compare IBD progression and healthcare resource utilization in patients with and without a co-diagnosis of IDA in a real-world setting. <\/jats:p><\/jats:sec><jats:sec><jats:title>Design:<\/jats:title><jats:p> A retrospective comparative study was conducted using Italian entities\u2019 administrative databases, covering 9.3 million health-assisted individuals. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Adult IBD patients diagnosed with ulcerative colitis and\/or Crohn\u2019s disease were enrolled between January 2010 and September 2017. Within 12\u2009months from IBD diagnosis, IDA was identified by at least one prescription for iron and\/or IDA hospitalization and\/or blood transfusion (proxy of diagnosis). IBD population was divided according to the presence\/absence of IDA. Given the nonrandom patients\u2019 allocation, propensity score matching (PSM) was applied to abate potential unbalances between the groups. Before and after PSM, IBD progression (in terms of IBD-related hospitalizations and surgeries), and healthcare resource costs were assessed. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Overall, 13,475 IBD patients were included, with an average age at diagnosis of 49.9\u2009years, and a 53.9% percentage of male gender. Before PSM, 1753 (13%) patients were IBD\u2013IDA, and 11,722 (87%) were IBD\u2013non-IDA. Post-PSM, 1753 IBD\u2013IDA patients were matched with 3506 IBD\u2013non-IDA. Before PSM, IBD progression was significantly higher in IBD\u2013IDA (12.8%) than in IBD\u2013non-IDA (6.5%) ( p\u2009&lt;\u20090.001). After PSM, IBD progression and IBD-related hospitalizations were significantly ( p\u2009&lt;\u20090.001) more frequent in IBD\u2013IDA patients (12.8% and 12.0%, respectively) compared to IBD\u2013non-IDA (8.7% and 7.7%). Consistently, healthcare expenditures resulted significantly higher among IDA patients ( p\u2009&lt;\u20090.001), with an overall mean annual cost of \u20ac5317 compared to \u20ac2798 for patients without IDA. These results were confirmed after PSM matching, as the mean annual total cost\/patient in IBD\u2013IDA versus IBD\u2013non-IDA were \u20ac3693 and \u20ac3046, respectively ( p\u2009&lt;\u20090.001). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> In a real-life setting, IDA co-diagnosis in IBD patients was associated with disease progression and higher related economic burden. <\/jats:p><\/jats:sec>","DOI":"10.1177\/17562848231177153","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T11:30:19Z","timestamp":1685446219000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Iron deficiency anemia impacts disease progression and healthcare resource consumption in patients with inflammatory bowel disease: a real-world evidence study"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5623-2968","authenticated-orcid":false,"given":"Gionata","family":"Fiorino","sequence":"first","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy, Vita-Salute San Raffaele University, Milan, Italy"},{"name":"Gastroenterology and Digestive Endoscopy, San Camillo-Forlanini Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Frederic","family":"Colombel","sequence":"additional","affiliation":[{"name":"Mount Sinai, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kostas","family":"Katsanos","sequence":"additional","affiliation":[{"name":"University of Ioannina, Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferm\u00edn","family":"Mearin","sequence":"additional","affiliation":[{"name":"Teknon Medical Center, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Stein","sequence":"additional","affiliation":[{"name":"DGD Kliniken Frankfurt Sachsenhausen, Frankfurt\/Main, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margherita","family":"Andretta","sequence":"additional","affiliation":[{"name":"Azienda ULSS 8 Berica, Vicenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Antonacci","sequence":"additional","affiliation":[{"name":"ASL Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loredana","family":"Arenare","sequence":"additional","affiliation":[{"name":"Asl Latina, Latina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Citraro","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero-Universitaria Mater Domini, Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Dell\u2019Orco","sequence":"additional","affiliation":[{"name":"ASL Roma 6, Albano Laziale, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7020-6659","authenticated-orcid":false,"given":"Luca","family":"Degli Esposti","sequence":"additional","affiliation":[{"name":"CliCon S.r.l. Societ\u00e0 Benefit Health, Economics & Outcomes Research, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Ramirez de Arellano Serna","sequence":"additional","affiliation":[{"name":"CSL Vifor, Glattbrugg, Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neige","family":"Morin","sequence":"additional","affiliation":[{"name":"CSL Vifor, Glattbrugg, Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis E.","family":"Koutroubakis","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospital Heraklion, P.O. BOX 1352, Heraklion, Crete 71110, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,5,30]]},"reference":[{"key":"bibr1-17562848231177153","unstructured":"McDowell C, Farooq U, Haseeb M. Inflammatory Bowel Disease. In: StatPearls [Internet]. 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