{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:06:39Z","timestamp":1785539199824,"version":"3.56.0"},"reference-count":64,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> In patients with inflammatory bowel disease (IBD), frailty is independently associated with mortality and morbidity. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives:<\/jats:title><jats:p> This study aimed to extend this work to determine the association between the clinical frailty scale (CFS), handgrip strength (HGS), and malnutrition with IBD-related hospitalizations and surgeries. <\/jats:p><\/jats:sec><jats:sec><jats:title>Design:<\/jats:title><jats:p> IBD patients \u2a7e18\u2009years of age were prospectively enrolled from two ambulatory care clinics in Alberta, Canada. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Frailty was defined as a CFS score \u2a7e4, dynapenia as HGS\u2009&lt;\u200916\u2009kg for females and &lt;27\u2009kg for males, malnutrition using the subjective global assessment (SGA), and the risk of malnutrition using either the abridged patient-generated SGA (abPG-SGA), or the Saskatchewan Inflammatory Bowel Disease Nutrition Risk Tool (SaskIBD-NRT). Logarithm relative hazard graphs and multivariable logistic regression models adjusting for relevant confounders were constructed. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> One hundred sixty-one patients (35% ulcerative colitis, 65% Crohn\u2019s disease) with a mean age of 42.2 (\u00b115.9) years were followed over a mean period of 43.9 (\u00b110.1) months. Twenty-seven patients were hospitalized, and 13 patients underwent IBD-related surgeries following baseline. While the CFS (aHR 1.34; p\u2009=\u20090.61) and SGA (aHR 0.81; p\u2009=\u20090.69) did not independently predict IBD-related hospitalizations, decreased HGS (aHR 3.96; p\u2009=\u20090.03), increased abPG-SGA score (aHR 1.07; p\u2009=\u20090.03) and a SaskIBD-NRT\u2009\u2a7e\u20095 (aHR 4.49; p\u2009=\u20090.02) did. No variable was independently associated with IBD-related surgeries. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> HGS, the abPG-SGA, and the SaskIBD-NRT were independently associated with an increased risk of IBD-related hospitalizations. Future studies should aim to validate other frailty assessments in the IBD population in order to better tailor care for all IBD patients. <\/jats:p><\/jats:sec>","DOI":"10.1177\/17562848231194395","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T11:48:26Z","timestamp":1693482506000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Handgrip strength and risk of malnutrition are associated with an increased risk of hospitalizations in inflammatory bowel disease patients"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5133-5853","authenticated-orcid":false,"given":"Katherine","family":"Bedard","sequence":"first","affiliation":[{"name":"Department of Medicine, Faculty of Graduate Studies and Research, University of Alberta, Edmonton, AB, 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