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AP-associated inflammation can lead to the gut barrier and function damage, causing dysbacteriosis and facilitating intestinal microbiota migration. Pancreatic exocrine deficiency and decreased levels of antimicrobial peptides in AP can also lead to abnormal growth of intestinal bacteria. Meanwhile, intestinal microbiota migration influences the pancreatic microenvironment and affects the severity of AP, which, in turn, exacerbates the systemic inflammatory response. Thus, the interaction between the gut microbiota (GM) and the inflammatory response may be a key pathogenic feature of SAP. Treating either of these factors or breaking their interaction may offer some benefits for SAP treatment. In this review, we discuss the mechanisms of interaction of the GM and inflammation in AP and factors that can deteriorate or even cure both, including some traditional Chinese medicine treatments, to provide new methods for studying AP pathogenesis and developing therapies. <\/jats:p>","DOI":"10.1177\/17562848231202133","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T12:18:36Z","timestamp":1696940316000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Gut microbiota interacts with inflammatory responses in acute pancreatitis"],"prefix":"10.1177","volume":"16","author":[{"given":"Linjun","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, China"},{"name":"Hospital of Chinese Traditional Medicine of Leshan, Leshan, 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