{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:44:59Z","timestamp":1791254699145,"version":"4.1.0"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Constipation is characterized by symptoms of straining, hard stool, difficult evacuation, and infrequent bowel movements. Online surveys provide valuable information about patients\u2019 perspectives, symptoms, management, treatment satisfaction, and risk factors. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> This survey explored subject experiences involving 20 gastrointestinal (GI) conditions. In total, 20,099 respondents in seven countries with varied cultural and socioeconomic backgrounds participated. Post hoc analysis of \u2018self-reported constipation\u2019 and related symptoms experienced within the past 6\u2009months and the last episode of constipation provided data on prevalence, demographics, frequency and duration of episodes and related symptoms, impact on quality of life (QoL), management with or without laxatives, and resulting treatment satisfaction. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> In total, 10,425 subjects reported constipation within 6\u2009months and 2637 at the last episode. Prevalence was highest in females and younger adults. Most subjects reported various coexisting GI symptoms. Almost 80% of 6865 episodes reported by 5337 subjects occurred every 2\u20133\u2009months to every 2\u20133\u2009weeks. A higher frequency of constipation correlated with a greater impact on QoL. On a 10-point scale, the mean impact was 6.4. More than 90% of respondents had episodes ranging from 1\u2009day to 1\u2009week. More than 90% took action; 16% used laxatives, of whom 80.3% were satisfied. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Constipation, a highly prevalent disorder, spans cultures and socioeconomic classes. Its chronic recurrence has a significant impact on QoL, resulting in symptom self-management in &gt;90% of subjects. Significantly higher satisfaction rates in subjects treated with than without laxatives reflect subjects\u2019 reports that self-reported constipation can be treated effectively with laxatives. <\/jats:p><\/jats:sec>","DOI":"10.1177\/17562848241232605","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T09:24:55Z","timestamp":1709544295000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Prevalence and patterns of laxative use in subjects with self-reported constipation: results from a multinational digestive health survey"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4121-7970","authenticated-orcid":false,"given":"Brian E.","family":"Lacy","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Mayo Clinic, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9gis","family":"Delfini","sequence":"additional","affiliation":[{"name":"Sanofi, Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernward","family":"Fladung","sequence":"additional","affiliation":[{"name":"Freelance Medical Advisor, Linnich, Germany"},{"name":"R\u00e9gis Delfini is currently affiliated to Boehringer Ingelheim, Ingelheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Lange","sequence":"additional","affiliation":[{"name":"Industriepark Hoechst, Building K 607, 65929 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,3,4]]},"reference":[{"key":"bibr1-17562848241232605","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010631"},{"key":"bibr2-17562848241232605","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.12.034"},{"key":"bibr3-17562848241232605","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10010143"},{"key":"bibr4-17562848241232605","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03806.x"},{"key":"bibr5-17562848241232605","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.04.014"},{"key":"bibr6-17562848241232605","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1053\/j.gastro.2016.02.011","volume":"150","author":"Mearin F","year":"2016","journal-title":"Gastroenterology"},{"key":"bibr7-17562848241232605","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.95"},{"key":"bibr8-17562848241232605","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0243318"},{"key":"bibr9-17562848241232605","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001222"},{"key":"bibr10-17562848241232605","volume":"25","author":"Lacy BE","year":"2019","journal-title":"Am J Manag Care"},{"key":"bibr11-17562848241232605","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12124"},{"key":"bibr12-17562848241232605","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-311835"},{"key":"bibr13-17562848241232605","doi-asserted-by":"publisher","DOI":"10.4292\/wjgpt.v7.i2.274"},{"key":"bibr14-17562848241232605","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2019.01.031"},{"key":"bibr15-17562848241232605","doi-asserted-by":"publisher","DOI":"10.1097\/01.WON.0000438019.21229.b7"},{"key":"bibr16-17562848241232605","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2008.04.016"},{"key":"bibr17-17562848241232605","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-12-78"},{"key":"bibr18-17562848241232605","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2009.09.001"},{"key":"bibr19-17562848241232605","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01642.x"},{"key":"bibr20-17562848241232605","doi-asserted-by":"publisher","DOI":"10.1177\/2050640615603009"},{"key":"bibr21-17562848241232605","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000141"},{"key":"bibr22-17562848241232605","doi-asserted-by":"publisher","DOI":"10.1159\/000488695"},{"key":"bibr23-17562848241232605","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-018-4995-6"},{"key":"bibr24-17562848241232605","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2019.02.017"},{"key":"bibr25-17562848241232605","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-019-1115-4"},{"key":"bibr26-17562848241232605","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12937"},{"key":"bibr27-17562848241232605","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.05259.x"},{"key":"bibr28-17562848241232605","doi-asserted-by":"publisher","DOI":"10.1177\/2050640613494200"},{"key":"bibr29-17562848241232605","doi-asserted-by":"publisher","DOI":"10.4236\/ojgas.2017.71005"},{"key":"bibr30-17562848241232605","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03238.x"},{"key":"bibr31-17562848241232605","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2015.02.004"}],"container-title":["Therapeutic Advances in Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562848241232605","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17562848241232605","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562848241232605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T04:42:10Z","timestamp":1740804130000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17562848241232605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":31,"alternative-id":["10.1177\/17562848241232605"],"URL":"https:\/\/doi.org\/10.1177\/17562848241232605","relation":{},"ISSN":["1756-2848","1756-2848"],"issn-type":[{"value":"1756-2848","type":"print"},{"value":"1756-2848","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"17562848241232605"}}