{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T17:44:16Z","timestamp":1785519856888,"version":"3.56.0"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Belgian Health Care Knowledge Centre (KCE) Trials Program","award":["KCE16001"],"award-info":[{"award-number":["KCE16001"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction characterized by recurrent abdominal pain related to defecation and\/or associated to a change in bowel habits. According to the stool type, four different IBS subtypes can be recognized, constipation predominant (IBS-C), diarrhea predominant (IBS-D), mixed (IBS-M), and undefined (IBS-U). Patients report that their IBS symptoms are exacerbated by food. Thus, it is important to find a nutritional approach that could be effective in reducing IBS symptoms. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objective:<\/jats:title><jats:p> The present work is a post hoc analysis of the previously published DOMINO trial. It aimed to evaluate the effects of a self-instructed FODMAP-lowering diet smartphone application on symptoms and psychosocial aspects in primary care IBS stratifying the results for each IBS subtypes. <\/jats:p><\/jats:sec><jats:sec><jats:title>Design:<\/jats:title><jats:p> Post hoc analysis. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Two hundred twenty-two primary care IBS patients followed a FODMAP-lowering diet for 8\u2009weeks with the support of a smartphone application. Two follow-up visits were scheduled after 16 and 24\u2009weeks. IBS\u2013Symptoms Severity Score (IBS-SSS), quality of life (QoL), and adherence and dietary satisfaction were evaluated. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> After 8\u2009weeks, IBS-SSS improved in all IBS subtypes ( p\u2009&lt;\u20090.0001). Physician Health Questiionnaire (PHQ-15) improved only in IBS-D ( p\u2009=\u20090.0006), whereas QoL improved both in IBS-D ( p\u2009=\u20090.01) and IBS-M ( p\u2009=\u20090.005). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> This post hoc analysis showed that the app is useful in all IBS subtypes; thus, it could be used as an effective tool by both general practitioners and patients to manage symptoms in primary care. <\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration:<\/jats:title><jats:p> Ethical Commission University Hospital of Leuven reference number: S59482. Clinicaltrial.gov reference number: NCT04270487. <\/jats:p><\/jats:sec>","DOI":"10.1177\/17562848241255296","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T06:23:13Z","timestamp":1722406993000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["DOMINO trial <i>post hoc<\/i> analysis: evaluation of the diet effects on symptoms in IBS subtypes"],"prefix":"10.1177","volume":"17","author":[{"given":"Claudia","family":"Di Rosa","sequence":"first","affiliation":[{"name":"Campus Bio-Medico University, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Van den Houte","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Diseases (TARGID), Department of Chronic Diseases and Metabolism (ChroMeta), University of Leuven, Leuven, 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