{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:56:52Z","timestamp":1790611012025,"version":"4.1.0"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wellcome Trust Clinical Research Career Development Fellowship"},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/N013166\/1"],"award-info":[{"award-number":["MR\/N013166\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","award":["MR\/S034919\/1"],"award-info":[{"award-number":["MR\/S034919\/1"]}],"id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Long-term vedolizumab (VDZ) outcomes in real-world cohorts have been largely limited to 1-year follow-up, with few bio-na\u00efve patients or objective markers of inflammation assessed. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives:<\/jats:title><jats:p> We aimed to assess factors affecting VDZ persistence including clinical, biochemical and faecal biomarker remission at 1, 3 and 5\u2009years. <\/jats:p><\/jats:sec><jats:sec><jats:title>Design:<\/jats:title><jats:p> We performed a retrospective, observational, cohort study. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> All adult inflammatory bowel disease (IBD) patients who had received VDZ induction for ulcerative colitis (UC)\/IBD-unclassified (IBDU) were included. Baseline phenotype and follow-up data were collected via a review of electronic medical records. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> We included 290 patients [UC n\u2009=\u2009271 (93.4%), IBDU n\u2009=\u200919 (6.6%)] with a median time on VDZ of 27.6\u2009months (interquartile range: 14.4\u201343.2). At the end of follow-up, a total of 157\/290 (54.1%) patients remained on VDZ. The median time to discontinuation was 14.1\u2009months (7.0\u201323.3). Previous exposure to \u2a7e1 advanced therapy, steroid use at baseline and disease extension (E3 and E2 versus E1) were independent predictors for worse VDZ persistence. Clinical remission (partial Mayo\u2009&lt;\u20092) was 75.7% (171\/226), 72.4% (157\/217) and 70.2% (127\/181) at years 1, 3 and 5, respectively. Steroid use during maintenance VDZ therapy occurred in 31.7% (92\/290), hospitalization in 15.5% (45\/290) and surgery in 3.4% (10\/291). The rate of serious adverse events was 1.2\u2009per 100 patient-years of follow-up. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> VDZ effectiveness appears enduring with favourable long-term safety profile. VDZ persistence was influenced by previous exposure to biologics\/small molecules, disease distribution and steroid use at baseline in our study. <\/jats:p><\/jats:sec>","DOI":"10.1177\/17562848241258372","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T06:23:45Z","timestamp":1722407025000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Long-term outcomes and predictors of vedolizumab persistence in ulcerative colitis"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5628-313X","authenticated-orcid":false,"given":"Beatriz","family":"Gros","sequence":"first","affiliation":[{"name":"Edinburgh IBD Unit, Western General Hospital, Edinburgh, Scotland, UK"},{"name":"Department of Gastroenterology; Liver and Digestive Diseases Networking Biomedical Research Centre (CIBEREHD), Madrid, Spain and Hepatology, Reina Sof\u00eda University Hospital, C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Ross","sequence":"additional","affiliation":[{"name":"Edinburgh IBD Unit, Western General Hospital, Edinburgh, Scotland, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Nwabueze","sequence":"additional","affiliation":[{"name":"Edinburgh IBD Unit, Western General Hospital, Edinburgh, Scotland, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Constantine-Cooke","sequence":"additional","affiliation":[{"name":"MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK"},{"name":"Centre for Genomics and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauranne A. A. P.","family":"Derikx","sequence":"additional","affiliation":[{"name":"Edinburgh IBD Unit, Western General Hospital, Edinburgh, Scotland, UK Inflammatory Bowel Disease Center, Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands"},{"name":"Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew","family":"Lyons","sequence":"additional","affiliation":[{"name":"Edinburgh IBD Unit, Western General Hospital, Edinburgh, Scotland, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"O\u2019Hare","sequence":"additional","affiliation":[{"name":"Edinburgh IBD Unit, Western General Hospital, Edinburgh, Scotland, UK"},{"name":"Edinburgh Pharmacy Unit, Western General Hospital, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Noble","sequence":"additional","affiliation":[{"name":"Edinburgh IBD Unit, Western General Hospital, Edinburgh, Scotland, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian D.","family":"Arnott","sequence":"additional","affiliation":[{"name":"Edinburgh IBD Unit, Western General Hospital, Edinburgh, Scotland, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth-Rhys","family":"Jones","sequence":"additional","affiliation":[{"name":"Edinburgh IBD Unit, Western General Hospital, Edinburgh, Scotland, UK"},{"name":"Centre for Inflammation Research, The Queen\u2019s Medical Research Institute, University of Edinburgh, Scotland, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlie W.","family":"Lees","sequence":"additional","affiliation":[{"name":"Edinburgh IBD Unit, Western General Hospital, NHS Lothian, Crewe Road, Edinburgh EH4 2XU, UK"},{"name":"Centre for Genomics and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolas","family":"Plevris","sequence":"additional","affiliation":[{"name":"Edinburgh IBD Unit, Western General Hospital, Edinburgh, Scotland, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"key":"bibr1-17562848241258372","unstructured":"EMA recommends approval of a locally targeted treatment for ulcerative colitis and Crohn\u2019s disease. https:\/\/www.ema.europa.eu\/en\/documents\/press-release\/european-medicines-agency-recommends-approval-locally-targeted-treatment-ulcerative-colitis-crohns_en.pdf (2014, accessed 20 February 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