{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:15:31Z","timestamp":1787019331500,"version":"build-2736575974"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Complex fistulizing perianal disease is a disabling manifestation of inflammatory bowel disease (IBD), seriously compromising patients \u2018quality of life\u2019. The success rate of available treatments is quite low, and nearly half of the patients will develop chronically active fistulas or experience fistula recurrence. Mesenchymal stem cell therapy has shown interesting results, but the complexity and the cost of production limit its widespread use. This study aims to report the results of the innovative use of autologous emulsified adipose-derived stromal vascular fraction tissue for treating complex fistulizing perianal disease. From March 2021 to March 2022, 10 patients underwent a two-step procedure: (1) examination under anaesthesia, with loose seton drainage and 4\u2009weeks later and (2) curettage of the fistulous tract, internal fistula closure and an injection of autologous emulsified adipose-derived stromal vascular fraction tissue harvested from the subcutaneous layer of the patient\u2019s hip. Clinical and radiological (through magnetic resonance imaging) healing were assessed at 6\u2009months. We included five patients affected by Crohn\u2019s disease, three by ulcerative colitis and two by indeterminate colitis. All patients were on concomitant biological therapy (50% on Infliximab). One patient required a re-treatment for a relapse and two different fistulas were separately treated in another one. Out of 12 total procedures performed, clinical healing was achieved in 10 cases (83%), while radiological healing in 6 patients (50%). No adverse events were recorded. Autologous emulsified adipose-derived stromal vascular fraction tissue can represent an effective, safe and cheap add-on therapy for patients with complex perianal fistulas in IBDs.<\/jats:p>","DOI":"10.1177\/17562848241263014","type":"journal-article","created":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T00:27:22Z","timestamp":1725668842000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Effectiveness of autologous emulsified stromal vascular fraction tissue injection for the treatment of complex perianal fistulas in inflammatory bowel diseases patients: a pilot study"],"prefix":"10.1177","volume":"17","author":[{"given":"Angelo Eugenio","family":"Potenza","sequence":"first","affiliation":[{"name":"Abdominal Surgery Unit, Department of Gastroenterological, Endocrine-Metabolic and Nephro-Urological Sciences, Fondazione Policlinico Universitario \u2018A. Gemelli\u2019 IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dania","family":"Nachira","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery, Fondazione Policlinico Universitario \u2018A. Gemelli\u2019 IRCCS, Universit\u00e0 Cattolica del Sacro Cuore, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8704-2171","authenticated-orcid":false,"given":"Franco","family":"Sacchetti","sequence":"additional","affiliation":[{"name":"Abdominal Surgery Unit, Department of Gastroenterological, Endocrine-Metabolic and Nephro-Urological Sciences, Fondazione Policlinico Universitario \u2018A. Gemelli\u2019 IRCCS, L. go A. Gemelli 8, Rome 00168, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Trivisonno","sequence":"additional","affiliation":[{"name":"Unit of Plastic Surgery, Assunzione di Maria Santissima Clinic, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Pugliese","sequence":"additional","affiliation":[{"name":"IBD Unit, CEMAD Centro Malattie dell\u2019Apparato Digerente, Medicina Interna e Gastroenterologia Fondazione Policlinico Universitario Gemelli IRCCS, Roma, Italy"},{"name":"Dipartimento di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8194-2670","authenticated-orcid":false,"given":"Ivo","family":"Bo\u0161koski","sequence":"additional","affiliation":[{"name":"Center for Endoscopic Research Therapeutics and Training, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"},{"name":"Digestive Endoscopy Unit, Fondazione Policlinico Universitario \u2018A. Gemelli\u2019 IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Caudullo","sequence":"additional","affiliation":[{"name":"School of General Surgery, Universit\u00e0 Cattolica del Sacro Cuore, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Maria","family":"Minordi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Oncological Radiotherapy, and Hematology, Fondazione Policlinico Universitario \u2018A. Gemelli\u2019 IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Larosa","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Oncological Radiotherapy, and Hematology, Fondazione Policlinico Universitario \u2018A. Gemelli\u2019 IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Caprino","sequence":"additional","affiliation":[{"name":"Abdominal Surgery Unit, Department of Gastroenterological, Endocrine-Metabolic and Nephro-Urological Sciences, Fondazione Policlinico Universitario \u2018A. Gemelli\u2019 IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Scaldaferri","sequence":"additional","affiliation":[{"name":"IBD Unit, CEMAD Centro Malattie dell\u2019Apparato Digerente, Medicina Interna e Gastroenterologia Fondazione Policlinico Universitario Gemelli IRCCS, Roma, Italy"},{"name":"Dipartimento di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Sofo","sequence":"additional","affiliation":[{"name":"Abdominal Surgery Unit, Department of Gastroenterological, Endocrine-Metabolic and Nephro-Urological Sciences, Fondazione Policlinico Universitario \u2018A. Gemelli\u2019 IRCCS, Universit\u00e0 Cattolica del Sacro Cuore, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venanzio","family":"Porziella","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery, Fondazione Policlinico Universitario \u2018A. Gemelli\u2019 IRCCS, Universit\u00e0 Cattolica del Sacro Cuore, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"key":"bibr1-17562848241263014","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.32362"},{"key":"bibr2-17562848241263014","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e31825228b0"},{"key":"bibr3-17562848241263014","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz187"},{"key":"bibr4-17562848241263014","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000148"},{"key":"bibr5-17562848241263014","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-023-01912-z"},{"key":"bibr6-17562848241263014","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31203-X"},{"key":"bibr7-17562848241263014","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.12.020"},{"key":"bibr8-17562848241263014","first-page":"62","volume":"24","author":"Vosough M","year":"2022","journal-title":"Cell J"},{"key":"bibr9-17562848241263014","first-page":"154","volume":"101","author":"Leng\u00e1lov\u00e1 M","year":"2022","journal-title":"Rozhl Chir"},{"key":"bibr10-17562848241263014","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X657855"},{"key":"bibr11-17562848241263014","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-018-1755-8"},{"key":"bibr12-17562848241263014","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izz051"},{"key":"bibr13-17562848241263014","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.12.063"},{"key":"bibr14-17562848241263014","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.19-0166"},{"key":"bibr15-17562848241263014","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-201554"},{"key":"bibr16-17562848241263014","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastro.2003.08.025"},{"key":"bibr17-17562848241263014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07592.x"},{"key":"bibr18-17562848241263014","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000002325"},{"key":"bibr19-17562848241263014","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-019-02024-8"},{"key":"bibr20-17562848241263014","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-01636-4"}],"container-title":["Therapeutic Advances in Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562848241263014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17562848241263014","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562848241263014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T11:42:40Z","timestamp":1741002160000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17562848241263014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":20,"alternative-id":["10.1177\/17562848241263014"],"URL":"https:\/\/doi.org\/10.1177\/17562848241263014","relation":{},"ISSN":["1756-2848","1756-2848"],"issn-type":[{"value":"1756-2848","type":"print"},{"value":"1756-2848","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"17562848241263014"}}