{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:28:18Z","timestamp":1791502098769,"version":"4.3.4"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Ustekinumab (UST) is an effective treatment option in Crohn\u2019s disease (CD) and ulcerative colitis (UC). However, it still remains unclear if therapeutic drug monitoring could be helpful to guide clinicians. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives:<\/jats:title><jats:p> The aim of our study was to analyze the relationship between UST through levels (UST<jats:sub>TL<\/jats:sub>) and clinical outcomes in real-world inflammatory bowel disease (IBD) patients. <\/jats:p><\/jats:sec><jats:sec><jats:title>Design:<\/jats:title><jats:p> We performed a unicentric retrospective study including patients with IBD under UST treatment with at least one level determination. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> The following variables were analyzed at the initiation of UST and at each UST<jats:sub>TL<\/jats:sub> measurement: clinical response and remission using the Harvey\u2013Bradshaw Index (HBI) for CD and the Partial Mayo Score (pMayo) for UC; biochemical response and remission using fecal calprotectin and C-reactive protein, among others. Two periods were considered: P1 (time between induction and the first determination of UST<jats:sub>TL<\/jats:sub>) and P2 (time between UST<jats:sub>TL1<\/jats:sub> and the second determination of UST<jats:sub>TL<\/jats:sub>). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> We included 125 patients, 117 with CD. In P1, 62.4% of patients were on subcutaneous maintenance, and the median UST<jats:sub>TL1<\/jats:sub> was 3.1\u2009\u03bcg\/mL (1.6\u20135.3). In 44.8% of CD patients (48\/117), clinical remission was achieved, with UST<jats:sub>TL1<\/jats:sub> significantly higher than those who did not achieve remission (3.7\u2009\u03bcg\/mL (2.3\u20135.4) vs 2.3\u2009\u03bcg\/mL (1.1\u20135.2); p\u2009=\u20090.04). In the 46 patients with two determinations, statistically significant differences were found between variables in P2 versus P1: clinical remission (73.9% vs 21.7%; p\u2009=\u20090.001); UST<jats:sub>TL<\/jats:sub> (7.2\u2009\u03bcg\/mL (4.7\u201311.7) vs 3.4\u2009\u03bcg\/mL (1.9\u20136.4); p\u2009&lt;\u20090.001), HBI (4 (4\u20134.3) vs 8 (4\u20139); p\u2009&lt;\u20090.001), pMayo (1 (1\u20133.3) vs 4.5 (3\u20135); p\u2009=\u20090.042), and corticosteroid use (26.1% vs 41.3%; p\u2009=\u20090.024). Receiver-Operating-Characteristic (ROC) curves were calculated for clinical remission in P2, with UST<jats:sub>TL<\/jats:sub> cutoff value of 6.34\u2009\u03bcg\/mL for clinical remission and a high rate of intensified patients (98%). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> High serum levels of UST were associated with clinical remission during treatment for IBD under intensification treatment, with a cutoff point of 6.3\u2009\u03bcg\/mL. <\/jats:p><\/jats:sec>","DOI":"10.1177\/17562848241271980","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T13:41:52Z","timestamp":1725975712000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["High serum levels of ustekinumab are associated with better clinical outcomes during maintenance treatment for inflammatory bowel disease"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7105-3648","authenticated-orcid":false,"given":"Jaime","family":"Gonz\u00e1lez-Antu\u00f1a","sequence":"first","affiliation":[{"name":"Gastroenterology Department, Virgen Macarena University Hospital, Dr. Fedriani Avenue, 3, Seville 41009, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2142-5142","authenticated-orcid":false,"given":"Teresa","family":"Vald\u00e9s-Delgado","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Virgen Macarena University Hospital, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Maldonado-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Virgen Macarena University Hospital, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Belvis-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Virgen Macarena University Hospital, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Castro-Laria","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Virgen Macarena University Hospital, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Merino-Boh\u00f3rquez","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Virgen Macarena University Hospital, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"Calleja-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Virgen Macarena University Hospital, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Castro-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Seville, Seville, Andaluc\u00eda, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cloe","family":"Charpentier","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Rouen University Hospital, Rouen, Normandy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Arg\u00fcelles-Arias","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Virgen Macarena University Hospital, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"key":"bibr1-17562848241271980","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz180"},{"key":"bibr2-17562848241271980","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjab178"},{"key":"bibr3-17562848241271980","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastrohep.2024.01.007"},{"key":"bibr4-17562848241271980","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1900750"},{"key":"bibr5-17562848241271980","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjab070"},{"key":"bibr6-17562848241271980","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izab357"},{"key":"bibr7-17562848241271980","author":"Fumery M","year":"2020","journal-title":"J Crohns 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