{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T03:07:42Z","timestamp":1767409662083,"version":"3.41.2"},"reference-count":104,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","award":["This article was initiated and funded by Takeda UK"],"award-info":[{"award-number":["This article was initiated and funded by Takeda UK"]}],"id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p> Crohn\u2019s disease (CD) is a chronic inflammatory bowel disease (IBD) characterised by endoscopic inflammation, progressive bowel damage and gastrointestinal lesions. Although treatment strategies for CD have traditionally focused on a stepwise pharmacological approach to achieve clinical remission or symptom resolution, these treatment goals correlate poorly with disease activity. Thus, achieving full clinical remission and full endoscopic healing alone may be insufficient, as patients may remain at risk of inflammatory complications. Individualised \u2018treat-to-target\u2019 (T2T) pharmacological and treatment approaches represent a promising strategy for improving endoscopic remission and symptom resolution among patients with CD. The Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) and STRIDE-II guidelines, launched in 2013 and later renewed, identified individualised targets for a T2T therapeutic approach for patients with IBD. These guidelines facilitate the individualisation of target treatment goals through evidence-based, long-term (health-related quality of life, absence of disability, endoscopic healing) and intermediate\/short-term (abdominal pain, stool frequency, normalisation of biomarker levels) treatment targets, allowing patients and clinicians to consider the risk-to-benefit balance of goals and selected therapeutic strategies. This article aims to summarise the STRIDE-II guidelines and provide intellectual guidance for healthcare professionals to apply the STRIDE-II principles to current clinical practice in the United Kingdom (UK). Management recommendations for primary and secondary first-line non-responders are provided, along with suggestions for utilising the endoscopic outcomes scoring system in UK clinical practice. <\/jats:p><jats:p> [Box: see text] <\/jats:p>","DOI":"10.1177\/17562848241280885","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T13:31:16Z","timestamp":1730986276000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Crohn\u2019s disease management: translating STRIDE-II for UK clinical practice"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4528-6319","authenticated-orcid":false,"given":"Karen","family":"Kemp","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Manchester Clinical Academic Centre, Manchester Royal Infirmary, University of Manchester, Oxford Road, Manchester M13 9WL, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Samaan","sequence":"additional","affiliation":[{"name":"Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, St Thomas\u2019 Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay M.","family":"Verma","sequence":"additional","affiliation":[{"name":"Kettering General Hospital NHS Foundation Trust, Kettering, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan J.","family":"Lobo","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Broomhill, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"bibr1-17562848241280885","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31711-1"},{"key":"bibr2-17562848241280885","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2017.04.010"},{"key":"bibr3-17562848241280885","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199812000-00005"},{"key":"bibr4-17562848241280885","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.11.056"},{"key":"bibr5-17562848241280885","doi-asserted-by":"publisher","DOI":"10.1159\/000506364"},{"key":"bibr6-17562848241280885","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12336"},{"key":"bibr7-17562848241280885","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.59"},{"key":"bibr8-17562848241280885","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz131"},{"key":"bibr9-17562848241280885","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12196292"},{"key":"bibr10-17562848241280885","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.233"},{"key":"bibr11-17562848241280885","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.12.031"},{"key":"bibr12-17562848241280885","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.03.039"},{"key":"bibr13-17562848241280885","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32641-7"},{"key":"bibr14-17562848241280885","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61908-5"},{"key":"bibr15-17562848241280885","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.11.005"},{"key":"bibr16-17562848241280885","doi-asserted-by":"publisher","DOI":"10.15403\/jgld.2014.1121.273.pti"},{"key":"bibr17-17562848241280885","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000001082"},{"key":"bibr18-17562848241280885","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000273"},{"key":"bibr19-17562848241280885","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002458"},{"key":"bibr20-17562848241280885","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.08.022"},{"key":"bibr21-17562848241280885","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.11.034"},{"key":"bibr22-17562848241280885","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izx072"},{"key":"bibr23-17562848241280885","unstructured":"National Institute for Health and Care Excellence (NICE). 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