{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:34:51Z","timestamp":1790231691461,"version":"4.1.0"},"reference-count":35,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2507300"],"award-info":[{"award-number":["2023YFC2507300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangdong Provincial Clinical Research Center for Digestive Diseases","award":["2020B1111170004"],"award-info":[{"award-number":["2020B1111170004"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100544"],"award-info":[{"award-number":["82100544"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the program of Guangdong Provincial Clinical Research Center for Digestive Diseases","award":["2020B1111170004"],"award-info":[{"award-number":["2020B1111170004"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> No head-to-head trial directly compares the effectiveness of vedolizumab (VDZ) and infliximab (IFX) in patients with ulcerative colitis (UC) who were na\u00efve to biologic therapy. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives:<\/jats:title><jats:p> We aimed to compare the clinical and endoscopic effectiveness of VDZ and IFX in biologic-na\u00efve patients with UC in real-world settings. <\/jats:p><\/jats:sec><jats:sec><jats:title>Design:<\/jats:title><jats:p> It was a multicenter, observational, real-world cohort study conducted at five centers. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Patients diagnosed with UC and treated with either IFX or VDZ as their first-line biologic therapy were retrospectively enrolled. Steroid-free remission, clinical response, clinical remission, and endoscopic healing at week 14 and week 52 were compared between the two groups after propensity score weighting. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> A total of 199 patients (117 VDZ and 82 IFX) were included in the study. There were no significant differences in steroid-free remission (64.6% vs 56.1%, p\u2009=\u20090.224), clinical response (83.4% vs 73.4%, p\u2009=\u20090.086), or clinical remission (69.4% vs 60.1%, p\u2009=\u20090.174) at week 14. However, VDZ showed better results in steroid-free remission (67.5% vs 44.4%, p\u2009=\u20090.004), clinical response (69.7% vs 47.1%, p\u2009=\u20090.005), and clinical remission (67.5% vs 44.4%, p\u2009=\u20090.004) at week 52. In terms of endoscopic healing, VDZ was similar to IFX at week 14 (25.7% vs 17.4%, p\u2009=\u20090.185), but VDZ had a significantly higher rate at week 52 (29.5% vs 11.8%, p\u2009=\u20090.027). VDZ was found to be superior to IFX in therapeutic continuation (hazard ratio\u2009=\u20090.339, 95% CI: 0.187\u20130.614, p\u2009&lt;\u20090.001). The rate of adverse events was similar between the two groups (6.8% vs 8.5%, p\u2009=\u20090.655). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> VDZ demonstrated similar clinical and endoscopic effectiveness to IFX at week 14 in biologic-na\u00efve patients with UC, but appeared to be superior at week 52. The safety outcomes were comparable between the groups. <\/jats:p><\/jats:sec>","DOI":"10.1177\/17562848241281218","type":"journal-article","created":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T12:04:36Z","timestamp":1728821076000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of clinical and endoscopic efficacy between vedolizumab and infliximab in bio-na\u00efve patients with ulcerative colitis: a multicenter, real-world study"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7689-6520","authenticated-orcid":false,"given":"Zhaopeng","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China"},{"name":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenke","family":"Chen","sequence":"additional","affiliation":[{"name":"Peking University Shenzhen Hospital, Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingna","family":"Lu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyue","family":"Xia","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China"},{"name":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongsheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China"},{"name":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China"},{"name":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zicheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen 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