{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:52:11Z","timestamp":1788900731081,"version":"build-2803163510"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002960","name":"V\u00e4sterbotten L\u00e4ns Landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002960","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Treatments and strategies for inflammatory bowel disease (IBD) have gradually evolved in the 2000s. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives:<\/jats:title><jats:p> We investigated whether the prescription of corticosteroids (prednisolone and budesonide) in patients with IBD in the first 5\u2009years after diagnosis changed in patients diagnosed between 2006 and 2018. <\/jats:p><\/jats:sec><jats:sec><jats:title>Design:<\/jats:title><jats:p> Retrospective observational study. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> The cumulative prescribed dosage of corticosteroids for the first 5\u2009years after diagnosis was registered in all patients with IBD ( n\u2009=\u2009386) at our clinic for those diagnosed between 2006 and 2018. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> The proportion of patients with IBD who were prescribed at least one prescription of corticosteroids in year 1\u20135 after diagnosis was 55.3%, 27.9%, 22.7%, 14.1%, and 14.6%, respectively. The proportion of patients who had a cumulative dose of prednisolone &gt;1\u2009g in the first 5\u2009years after diagnosis was 40.1% for ulcerative colitis and 34.9% for Crohn\u2019s disease (CD). The cumulative prescribed dosage (within 3\u2009years after diagnosis) of prednisolone had declined (rs\u2009=\u2009\u22120.164, p\u2009=\u2009001), but had increased for budesonide (rs\u2009=\u20090.202, p\u2009&lt;\u20090.001) between 2006 and 2020. The prescription of any immunomodulator for IBD in the first 5\u2009years from diagnosis was stable between 2006 and 2018 (rs\u2009=\u20090.056, p\u2009=\u20090.257), but there was a minor increase in the prescription of Tumor Necrosis Factor (TNF)-inhibitors (rs\u2009=\u20090.119, p\u2009=\u20090.020). The use of five-acetyl salicylic acid (5-ASA) decreased in patients with CD (rs\u2009=\u2009\u2212201, p\u2009=\u20090.012). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> There was a decrease in the prescription of prednisolone and an increase in the prescription of budesonide treatment from 2006 to 2023; however, the cumulative exposure to corticosteroids in patients with IBD remains at a relatively high level. <\/jats:p><\/jats:sec>","DOI":"10.1177\/17562848241288851","type":"journal-article","created":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T12:06:36Z","timestamp":1728821196000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Prescribed cumulative dosage of corticosteroids to patients with inflammatory bowel disease diagnosed between 2006 and 2020: a retrospective observational study"],"prefix":"10.1177","volume":"17","author":[{"given":"Johannes","family":"Iiristo","sequence":"first","affiliation":[{"name":"Department of Public Health and Clinical Medicine, Ume\u00e5 University, Umea, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5607-0118","authenticated-orcid":false,"given":"Pontus","family":"Karling","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine, Ume\u00e5 University, Umea, 901 87, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,13]]},"reference":[{"key":"bibr1-17562848241288851","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)11132-7"},{"key":"bibr2-17562848241288851","first-page":"23","volume":"13","author":"Viscido 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