{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T10:38:04Z","timestamp":1768473484677,"version":"3.49.0"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Esophagogastroduodenoscopy (EGD) is the gold standard method for diagnosing upper gastrointestinal (GI) pathology. Swedish guidelines recommend patients over 50\u2009years with new-onset dyspeptic symptoms undergo direct gastroscopy to rule out malignancy. However, the incidence of dysplasia or cancer in patients aged 61\u201370\u2009years remains unclear. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives:<\/jats:title><jats:p> To investigate the referral factors and endoscopic findings in patients aged 61\u201370\u2009years and compare the result with age groups 51\u201360 and 41\u201350\u2009years from our previous studies to establish whether there is an age cutoff for upper GI cancer risk. <\/jats:p><\/jats:sec><jats:sec><jats:title>Design:<\/jats:title><jats:p> A retrospective observational study was conducted to evaluate EGD referrals and outcomes in patients aged 61\u201370\u2009years. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> We analyzed EGD referrals for patients aged 61\u201370\u2009years within Region \u00d6rebro County from January 2019\u2013April 2020 to January 2022\u20132023. Clinical data, including symptoms, medications, and laboratory results, were collected from medical records. Statistical analysis, including odds ratios (OR) and positive predictive values (PPV), was conducted to evaluate pathological outcomes based on referral factors. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> A total of 1003 referrals were analyzed. Statistically significant differences in pathological findings were observed between the 41\u201350\u2009years reference group and the older groups (51\u201360\u2009years: OR 2.08, p\u2009&lt;\u20090.001; 61\u201370\u2009years: OR 3.05, p\u2009&lt;\u20090.001). However, no statistically significant difference in cancer incidence was found between the age groups. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> The most common pathological findings were benign, including hiatal hernia, gastroesophageal reflux disease\/esophagitis, or gastritis. The incidence of cancer was low in all three groups. These results suggest that the \u201ctest-and-treat\u201d strategy, currently recommended for patients under 50\u2009years, may be appropriate for patients aged 51\u201370\u2009years as well. <\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration:<\/jats:title><jats:p> NCT04585516. <\/jats:p><\/jats:sec>","DOI":"10.1177\/17562848241290446","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T14:17:22Z","timestamp":1730125042000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Assessing age-related risks of gastrointestinal pathologies: a comparative study of gastroscopy outcomes across decades"],"prefix":"10.1177","volume":"17","author":[{"given":"Lac","family":"Nguyen","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, and University Health Care Research Unit, Faculty of Medicine and Health, \u00d6rebro University, \u00d6rebro, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noora","family":"R\u00e4s\u00e4nen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, and University Health Care Research Unit, Faculty of Medicine and Health, \u00d6rebro University, \u00d6rebro, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippa","family":"Berggren","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, and University Health Care Research Unit, Faculty of Medicine and Health, \u00d6rebro University, \u00d6rebro, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6348-2308","authenticated-orcid":false,"given":"Michiel A. van","family":"Nieuwenhoven","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine and Health, \u00d6rebro University, S\u00f6dra Grev Rosengatan, \u00d6rebro SE-70182, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"bibr1-17562848241290446","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2020.08.015"},{"key":"bibr2-17562848241290446","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.05.041"},{"key":"bibr3-17562848241290446","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31288-5"},{"key":"bibr4-17562848241290446","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"bibr5-17562848241290446","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2016.10.005"},{"key":"bibr6-17562848241290446","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307843"},{"key":"bibr7-17562848241290446","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.05.031"},{"key":"bibr8-17562848241290446","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.011"},{"key":"bibr9-17562848241290446","volume":"114","author":"Agr\u00e9us L","year":"2017","journal-title":"L\u00e4kartidningen"},{"key":"bibr10-17562848241290446","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327737"},{"key":"bibr11-17562848241290446","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.154"},{"key":"bibr12-17562848241290446","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-320839"},{"key":"bibr13-17562848241290446","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000002260"},{"key":"bibr14-17562848241290446","doi-asserted-by":"publisher","DOI":"10.1177\/1756284820959225"},{"key":"bibr15-17562848241290446","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"issue":"2","key":"bibr16-17562848241290446","volume":"11","author":"Rajan S","year":"2019","journal-title":"Cureus"},{"key":"bibr17-17562848241290446","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32404-7"},{"key":"bibr18-17562848241290446","volume":"18","author":"Expert Panel on Gastrointestinal Imaging","year":"2021","journal-title":"J Am Coll Radiol"},{"key":"bibr19-17562848241290446","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13233577"},{"key":"bibr20-17562848241290446","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.04.006"},{"key":"bibr21-17562848241290446","doi-asserted-by":"publisher","DOI":"10.14740\/gr1370"},{"key":"bibr22-17562848241290446","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-011-0598-3"},{"key":"bibr23-17562848241290446","unstructured":"Standardiserade V\u00e5rdf\u00f6rlopp i Cancerv\u00e5rden\u2014L\u00e4gesrapport 2015. 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