{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T08:44:44Z","timestamp":1793781884874,"version":"4.6.1"},"reference-count":42,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["739593"],"award-info":[{"award-number":["739593"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005881","name":"Emberi Eroforr\u00e1sok Miniszt\u00e9riuma","doi-asserted-by":"publisher","award":["UNKP- 23-3 -SZTE-268"],"award-info":[{"award-number":["UNKP- 23-3 -SZTE-268"]}],"id":[{"id":"10.13039\/501100005881","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005881","name":"Emberi Eroforr\u00e1sok Miniszt\u00e9riuma","doi-asserted-by":"publisher","award":["UNKP-22-4 -SZTE-293"],"award-info":[{"award-number":["UNKP-22-4 -SZTE-293"]}],"id":[{"id":"10.13039\/501100005881","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005881","name":"Emberi Eroforr\u00e1sok Miniszt\u00e9riuma","doi-asserted-by":"publisher","award":["UNKP-22-4-SZTE-296"],"award-info":[{"award-number":["UNKP-22-4-SZTE-296"]}],"id":[{"id":"10.13039\/501100005881","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005881","name":"Emberi Eroforr\u00e1sok Miniszt\u00e9riuma","doi-asserted-by":"publisher","award":["UNKP-23-3-SZTE-317"],"award-info":[{"award-number":["UNKP-23-3-SZTE-317"]}],"id":[{"id":"10.13039\/501100005881","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015763","name":"Szegedi Tudom\u00e1nyegyetem","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012550","name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap","doi-asserted-by":"publisher","award":["125377"],"award-info":[{"award-number":["125377"]}],"id":[{"id":"10.13039\/501100012550","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012550","name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap","doi-asserted-by":"publisher","award":["129266"],"award-info":[{"award-number":["129266"]}],"id":[{"id":"10.13039\/501100012550","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012550","name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap","doi-asserted-by":"publisher","award":["134863"],"award-info":[{"award-number":["134863"]}],"id":[{"id":"10.13039\/501100012550","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012550","name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap","doi-asserted-by":"publisher","award":["143549"],"award-info":[{"award-number":["143549"]}],"id":[{"id":"10.13039\/501100012550","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012550","name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap","doi-asserted-by":"publisher","award":["BO\/00598\/19\/5"],"award-info":[{"award-number":["BO\/00598\/19\/5"]}],"id":[{"id":"10.13039\/501100012550","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023322","name":"Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Szegedi Tudom\u00e1nyegyetem","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> The usability of subcutaneous vedolizumab (s.c. VDZ) treatment in inflammatory bowel diseases (IBD; ulcerative colitis (UC), Crohn\u2019s disease (CD)) has been proven via clinical trials while real-world data collection is ongoing. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives:<\/jats:title><jats:p> Our study evaluates the effectiveness, safety, patients\u2019 preferences, and psychological factors associated with s.c. VDZ treatment, after switching from intravenous (i.v.) formulation. <\/jats:p><\/jats:sec><jats:sec><jats:title>Design:<\/jats:title><jats:p> Prospective, multicenter cohort study including IBD patients switching from i.v. VDZ to s.c. treatment and were evaluated over 52\u2009weeks. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Serum VDZ levels and C-reactive protein (CRP) were measured at the baseline and w52. At w12, a questionnaire on the patient\u2019s satisfaction and psychological characteristics was administered. The primary outcome was the drug persistence rate (cessation was due to loss of response (LOR), adverse events, patient request, and other causes) at w52, while the secondary outcomes were the changes in the clinical corticosteroid-free remission (CSFR) and biochemical remission (BR; CRP\u2009\u2a7d\u20095\u2009mg\/L) rates, safety issues, serum drug levels, patients\u2019 preferences, and psychological features. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> In total, 70 IBD patients were evaluated (32 CD patients, 38 UC patients; male\/female ratio: 41.4%; median age: 43.2\u2009years). In the CD group, 81.3% were in CSFR and 65.6% were in BR, while in the UC group, 71.7% were in CSFR and 69.4% were in BR. Overall, 17.1% of the patients ceased s.c. VDZ treatment after a median of 26.2 (interquartile range 20\u201347)\u2009weeks. LOR was registered in 3\/12 ceased patients. In addition, CSFR and BR rates were stable, while serum VDZ levels increased by w52 ( p\u2009&lt;\u20090.001). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> The transition from i.v. to s.c. VDZ treatment was effective, the overall persistence rate was associated with high serum drug levels, and no novel safety issues were reported. Although s.c. administration after induction can save resources, some patients still insisted on i.v. VDZ treatment, due to its proven formulation. <\/jats:p><\/jats:sec>","DOI":"10.1177\/17562848241290636","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T01:13:46Z","timestamp":1729127626000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Outcomes of treatment cessation after switching to subcutaneous vedolizumab treatment in inflammatory bowel diseases"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8534-0068","authenticated-orcid":false,"given":"P\u00e9ter","family":"Bacsur","sequence":"first","affiliation":[{"name":"Department of Medicine, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, Szeged, Hungary"},{"name":"HCEMM-USZ Translational Colorectal Research Group, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3842-9094","authenticated-orcid":false,"given":"Tam\u00e1s","family":"Res\u00e1l","sequence":"additional","affiliation":[{"name":"Department of Medicine, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5086-9455","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Sarl\u00f3s","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, First Department of Medicine, Medical School, University of P\u00e9cs, P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1kos","family":"Ili\u00e1s","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Oncology, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liza","family":"Dalma S\u00fcmegi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Oncology, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di\u00e1na","family":"Kata","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anett","family":"D\u00e1vid","sequence":"additional","affiliation":[{"name":"Department of Medicine, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8816-0138","authenticated-orcid":false,"given":"Bernadett","family":"Farkas","sequence":"additional","affiliation":[{"name":"Department of Medicine, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emese","family":"Iv\u00e1ny","sequence":"additional","affiliation":[{"name":"Department of Medicine, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"B\u00e1lint","sequence":"additional","affiliation":[{"name":"Department of Medicine, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zs\u00f3fia","family":"B\u0151sze","sequence":"additional","affiliation":[{"name":"Department of Medicine, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0824-7476","authenticated-orcid":false,"given":"Anna","family":"F\u00e1bi\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Medicine, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9393-5240","authenticated-orcid":false,"given":"Ren\u00e1ta","family":"Bor","sequence":"additional","affiliation":[{"name":"Department of Medicine, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Szepes","sequence":"additional","affiliation":[{"name":"Department of Medicine, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waqqas","family":"Afif","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, McGill University Health Center, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talat","family":"Bessissow","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, McGill University Health Center, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaudia","family":"Farkas","sequence":"additional","affiliation":[{"name":"Department of Medicine, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, K\u00e1lv\u00e1ria Avenue 57, Szeged H-6725, Hungary"},{"name":"HCEMM-USZ Translational Colorectal Research Group, Szeged, H-6728, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3948-6488","authenticated-orcid":false,"given":"P\u00e9ter L.","family":"Lakatos","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, McGill University Health Centre, Montreal General Hospital, 1650 Avenue Cedar, D7-201, Montreal, QC H3G 1A4, Canada"},{"name":"Department of Internal Medicine and Oncology, Semmelweis University, Koranyi S 2A, Budapest H-1083, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4913-7599","authenticated-orcid":false,"given":"Tam\u00e1s","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Medicine, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, K\u00e1lv\u00e1ria Avenue 57, Szeged H-6725, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,16]]},"reference":[{"key":"bibr1-17562848241290636","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i1.91"},{"key":"bibr2-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.01.010"},{"key":"bibr3-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.01.008"},{"key":"bibr4-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.12.031"},{"key":"bibr5-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215739"},{"key":"bibr6-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215734"},{"key":"bibr7-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.106781"},{"key":"bibr8-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.10.032"},{"key":"bibr9-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1900750"},{"key":"bibr10-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602773"},{"key":"bibr11-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.02.068"},{"issue":"3","key":"bibr12-17562848241290636","volume":"158","author":"Sandborn WJ","year":"2020","journal-title":"Gastroenterology"},{"key":"bibr13-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjab133"},{"key":"bibr14-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1007\/s40259-018-0295-0"},{"key":"bibr15-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2020.09.002"},{"key":"bibr16-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2023.07.011"},{"key":"bibr17-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjab224"},{"key":"bibr18-17562848241290636","doi-asserted-by":"publisher","DOI":"10.3390\/ph16020239"},{"key":"bibr19-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2023.2176252"},{"key":"bibr20-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17153"},{"key":"bibr21-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16927"},{"key":"bibr22-17562848241290636","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12247657"},{"issue":"1","key":"bibr23-17562848241290636","first-page":"2024","volume":"360","author":"Wiken TH","journal-title":"Crohns Colitis"},{"key":"bibr24-17562848241290636","doi-asserted-by":"publisher","DOI":"10.15403\/jgld-5084"},{"key":"bibr25-17562848241290636","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60020296"},{"key":"bibr26-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"bibr27-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.082909"},{"key":"bibr28-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198712243172603"},{"key":"bibr29-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)92767-1"},{"key":"bibr30-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-200409000-00026"},{"key":"bibr31-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1207\/s15327752jpa6303_10"},{"key":"bibr32-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107108"},{"key":"bibr33-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1080\/08870440290001494"},{"key":"bibr34-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2005.10.020"},{"issue":"6","key":"bibr35-17562848241290636","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1556\/650.2021.31999","volume":"162","author":"L\u00e1tos M","year":"2021","journal-title":"Orvosi Hetilap"},{"key":"bibr36-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001552"},{"key":"bibr37-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21314"},{"key":"bibr38-17562848241290636","doi-asserted-by":"publisher","DOI":"10.4081\/hpr.2015.2206"},{"key":"bibr39-17562848241290636","unstructured":"The Jamovi Project. Jamovi. Version 2.0, Computer software, https:\/\/www.jamovi.org (2021, accessed 1 January 2023 to 31 December 2023)."},{"key":"bibr40-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izad166"},{"key":"bibr41-17562848241290636","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11247296"},{"key":"bibr42-17562848241290636","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2023-102380"}],"container-title":["Therapeutic Advances in Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562848241290636","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17562848241290636","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562848241290636","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T20:48:34Z","timestamp":1740862114000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17562848241290636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":42,"alternative-id":["10.1177\/17562848241290636"],"URL":"https:\/\/doi.org\/10.1177\/17562848241290636","relation":{},"ISSN":["1756-2848","1756-2848"],"issn-type":[{"value":"1756-2848","type":"print"},{"value":"1756-2848","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"17562848241290636"}}