{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T23:15:38Z","timestamp":1792278938615,"version":"4.4.0"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Current eradication regimens are not ideal for Helicobacter pylori infected patients who have difficulty choosing antibiotics due to penicillin allergy or antibiotic resistance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To explore the efficacy and safety of a simple vonoprazan-minocycline dual therapy (VM dual therapy) in H. pylori eradication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>\n                      Clinical data of patients who were prescribed 14-day VM dual therapy were retrospectively collected. The included patients were 18\u201370\u2009years old and positive for\n                      <jats:sup>13<\/jats:sup>\n                      C urea breath test (\n                      <jats:sup>13<\/jats:sup>\n                      C-UBT). They were allergic to penicillin or had a history of repeated antibiotic exposure or had failed eradication with multiple regimens containing amoxicillin. VM dual therapy consists of vonoprazan 20\u2009mg twice daily and minocycline 100\u2009mg twice daily.\n                      <jats:sup>13<\/jats:sup>\n                      C-UBT was repeated 4\u20136\u2009weeks after treatment to evaluate the therapeutic outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the 88 enrolled patients, 54 were treatment na\u00efve, 13 had one prior eradication failure, and 21 had multiple eradication failures. The overall intention to treat (ITT) and per-protocol (PP) eradication rates were 90.9% (95% CI: 82.4\u201395.7) and 95.2% (95% CI: 87.6\u201398.5). The ITT eradication rates were 90.7% (95% CI: 78.9\u201396.5) in treatment-na\u00efve patients, 84.6% (95% CI: 53.7\u201397.3) in patients with one prior treatment failure, and 95.2% (95% CI: 74.1\u201399.8) in patients with multiple failures. The PP eradication rates were 94.2% (95% CI: 83.1\u201398.5), 91.7% (95% CI: 59.8\u201399.6), and 100%, respectively. The overall incidence of adverse events was 23.0%. The common adverse reactions were nausea and mild dizziness, which could be resolved without intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Simple VM dual therapy exhibited a good eradication rate, low incidence of adverse effects, and good adherence. It is a potential new regimen for both first-line and rescue therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17562848241299734","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T23:16:03Z","timestamp":1732058163000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["The efficacy and safety of a simple 14-day vonoprazan-minocycline dual therapy for\n                    <i>Helicobacter pylori<\/i>\n                    eradication: a retrospective pilot study"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6568-2394","authenticated-orcid":false,"given":"Xiaolei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Peking University First Hospital, Beijing, 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