{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:55:52Z","timestamp":1793386552559,"version":"4.5.0"},"reference-count":12,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"This work was supported by The D\u2019Ambrosio Esophageal Research Fund"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Esophagogastric junction outflow obstruction (EGJOO) is a manometric diagnosis based on Chicago Classification version 4.0 (CC4.0) that requires confirmatory testing for clinical relevancy. However, it is still unclear which patients will respond to therapy. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives:<\/jats:title><jats:p> To evaluate manometric and clinical predictors of abnormal confirmatory testing for patients with EGJOO. <\/jats:p><\/jats:sec><jats:sec><jats:title>Design:<\/jats:title><jats:p> This was a prospective observational study of patients with manometric EGJOO and chest pain or dysphagia who underwent confirmatory testing. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Patients with EGJOO on manometry were enrolled and underwent timed barium esophagram or endoFLIP. A subset of patients was given validated surveys, including Eckardt scores (ES) and PROMIS-10. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> For patients with a CC4.0 EGJOO diagnosis, abnormal peristalsis (OR\u2009=\u20097.0, 95% CI\u2009=\u20091.01\u201344.6, p\u2009=\u20090.04) and increases in ES (OR\u2009=\u20092.34 95% CI\u2009=\u20091.13\u20134.86, p\u2009=\u20090.02) were associated with positive confirmatory testing. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Patients with potentially actionable EGJOO were more likely to have an abnormal peristaltic subtype of EGJOO or higher ES. <\/jats:p><\/jats:sec>","DOI":"10.1177\/17562848241306128","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T05:52:16Z","timestamp":1735019536000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Look above the IRP: predicting abnormal confirmatory testing in patients with esophagogastric junction outflow obstruction"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1019-5977","authenticated-orcid":false,"given":"Alexandra","family":"Strauss Starling","sequence":"first","affiliation":[{"name":"Division of Gastroenterology & Hepatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani U.","family":"Thanawala","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology & Hepatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire A.","family":"Beveridge","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Digestive Disease and Surgery Institute, Cleveland Clinic Foundation, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary W.","family":"Falk","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology & Hepatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristle L.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology & Hepatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Perelman Center for Advanced Medicine, 750 South 3400 Civic Center Blvd, Philadelphia, PA 19104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,12,23]]},"reference":[{"key":"bibr1-17562848241306128","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14058"},{"key":"bibr2-17562848241306128","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.12.041"},{"key":"bibr3-17562848241306128","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/dox004"},{"key":"bibr4-17562848241306128","first-page":"131","volume":"16","author":"Beveridge C","year":"2020","journal-title":"Gastroenterol Hepatol"},{"key":"bibr5-17562848241306128","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14555"},{"key":"bibr6-17562848241306128","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17101"},{"key":"bibr7-17562848241306128","unstructured":"von Elm E, Altman D, Egger M, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. 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