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Nevertheless, a subset of patients, refractory to available therapies, still requires proctocolectomy with ileal pouch-anal anastomosis (IPAA). Pouchitis, an inflammatory condition of the ileal pouch, is the most common long-term complication of IPAA, affecting almost one-half of patients in the first 10\u2009years after surgery. Symptoms of pouchitis include increased stool frequency, urgency, and abdominal discomfort, significantly affecting patients\u2019 quality of life. Traditionally the mainstay treatment of acute pouchitis involves the use of antibiotics, but one-fifth of patients develop chronic pouchitis (CP), which may be dependent or resistant to antibiotics, posing significant challenges in the management of this condition. Currently, there is still no consensus on the optimal management for CP, though recent progress in understanding the pathophysiology of pouchitis has paved the way for innovative therapeutic approaches, based on biological therapies and small molecules. This review aims to discuss the recent advanced therapies available for pouchitis and provide a comprehensive review on the topic to guide physicians in their clinical practice.<\/jats:p>","DOI":"10.1177\/17562848251316412","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T13:26:07Z","timestamp":1738157167000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Pouchitis unveiled: exploring clinical features, diagnosis, and cutting-edge treatments"],"prefix":"10.1177","volume":"18","author":[{"given":"Francesca","family":"Lusetti","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9854-3067","authenticated-orcid":false,"given":"Camilla Almeida","family":"Martins 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