{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:09:20Z","timestamp":1780484960485,"version":"3.54.1"},"reference-count":24,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82370604"],"award-info":[{"award-number":["82370604"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Natural Science Foundation of Fujian Province","award":["2023J01239"],"award-info":[{"award-number":["2023J01239"]}]},{"name":"the Major Science and Technology innovation Project of Fujian Province","award":["2023Y9269"],"award-info":[{"award-number":["2023Y9269"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> As an uncommon serological pattern, the effect of hepatitis B e antigen\/anti-hepatitis B e (HBeAg\/anti-HBe) coexistence on peginterferon-\u03b1 (Peg-IFN-\u03b1) therapy in patients with chronic hepatitis B (CHB) remains unknown. Moreover, Peg-IFN-\u03b1 is clinically limited due to several side effects. It is of significant value to early identify the favored population for Peg-IFN-\u03b1 therapy in CHB patients. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives:<\/jats:title><jats:p> This study aimed to analyze the impact of HBeAg\/anti-HBe coexistence on the effectiveness of Peg-IFN-\u03b1 and to construct a nomogram for predicting the occurrence of HBeAg seroconversion in treatment-na\u00efve CHB patients with Peg-IFN-\u03b1 therapy. <\/jats:p><\/jats:sec><jats:sec><jats:title>Design:<\/jats:title><jats:p> Retrospective, case\u2013control study of treatment-na\u00efve CHB patients with Peg-IFN-\u03b1 at a tertiary care center. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Data from HBeAg-positive treatment-na\u00efve CHB patients were retrospectively analyzed. Clinical characteristics of the HBeAg\/anti-HBe coexistence group were compared with those of the anti-HBe-negative group. In addition, univariate and multivariate logistic regression analyses were performed to identify independent risk factors for HBeAg seroconversion. The nomogram for the prediction of HBeAg seroconversion was constructed and evaluated. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> A total of 140 HBeAg-positive CHB patients were enrolled. Patients with HBeAg\/anti-HBe coexistence accounted for 11.4% of HBeAg-positive patients, and their hepatitis B surface antigen (HBsAg) and HBeAg levels were significantly lower than those of anti-HBe negative patients, but the HBeAg seroconversion rate was higher after Peg-IFN-\u03b1 treatment. As revealed by multivariate logistic analysis, HBeAg\/anti-HBe coexistence, baseline HBsAg, baseline HBeAg, and alanine aminotransferase ratio at baseline were independent correlates of HBeAg seroconversion. The nomogram model constructed based on these four independent correlates demonstrated good discrimination (area under the curve\u2009=\u20090.866), calibration, and clinical adaptability. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> HBeAg\/anti-HBe coexistence is associated with a higher HBeAg seroconversion rate, and the nomogram model constructed based on HBeAg\/anti-HBe coexistence performs well in predicting HBeAg seroconversion in treatment-na\u00efve CHB patients treated with Peg-IFN-\u03b1 therapy. <\/jats:p><\/jats:sec>","DOI":"10.1177\/17562848251318037","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T06:54:39Z","timestamp":1739256879000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of HBeAg\/anti-HBe coexistence on HBeAg seroconversion in treatment-na\u00efve chronic hepatitis B patients with peginterferon-\u03b1"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4483-064X","authenticated-orcid":false,"given":"Kaimin","family":"Song","sequence":"first","affiliation":[{"name":"Department of Infection Disease, Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian province, Fujian Medical University Affiliated First Quanzhou Hospital, Quanzhou, Fujian, China"},{"name":"Key Laboratory of Screening and Control of Infectious Diseases (Quanzhou Medical College), Fujian Provincial University, Quanzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huitong","family":"Wang","sequence":"additional","affiliation":[{"name":"Organ Transplantation Clinical Medical Center of Xiamen University, Department of Organ Transplantation, Xiang\u2019an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6923-5754","authenticated-orcid":false,"given":"Dawu","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Liver Center, The First Hospital Affiliated to Fujian Medical University, Fuzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyun","family":"Qian","sequence":"additional","affiliation":[{"name":"Organ Transplantation Clinical Medical Center of Xiamen University, Department of Organ Transplantation, Xiang\u2019an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiang","family":"Guo","sequence":"additional","affiliation":[{"name":"Organ Transplantation Clinical Medical Center of Xiamen University, Department of Organ Transplantation, Xiang\u2019an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huatang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infection Disease, Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian province, Fujian Medical University Affiliated First Quanzhou Hospital, Quanzhou, Fujian, China"},{"name":"Key Laboratory of Screening and Control of Infectious Diseases (Quanzhou Medical College), Fujian Provincial University, Quanzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijuan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Infection Disease, Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian province, Fujian Medical University Affiliated First Quanzhou Hospital, Quanzhou, Fujian, China"},{"name":"Key Laboratory of Screening and Control of Infectious Diseases (Quanzhou Medical College), Fujian Provincial University, Quanzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Bioengineering and Biotechnology, College of Life Sciences and Chemistry, Minnan Science and Technology University, Quanzhou, Fujian 362000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1157-2501","authenticated-orcid":false,"given":"Xueping","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Infection Disease, Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian province, Fujian Medical University Affiliated First Quanzhou Hospital, No. 250 East Street, Licheng District, Quanzhou, Fujian 362000, China"},{"name":"Key Laboratory of Screening and Control of Infectious Diseases (Quanzhou Medical College), Fujian Provincial University, Quanzhou, Fujian 362000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Infection Disease, Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian province, Fujian Medical University Affiliated First Quanzhou Hospital, No. 250 East Street, Licheng District, Quanzhou, Fujian 362000, China"},{"name":"Key Laboratory of Screening and Control of Infectious Diseases (Quanzhou Medical College), Fujian Provincial University, Quanzhou, Fujian 362000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"key":"bibr1-17562848251318037","first-page":"938","volume":"27","author":"Chinese Society of Infectious Diseases, Chinese Medical Association; Chinese Society of Hepatology, Chinese Medical Association","year":"2019","journal-title":"Zhonghua Gan Zang Bing Za 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