{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T23:49:24Z","timestamp":1794268164318,"version":"4.9.0"},"reference-count":49,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The Operative Link on Gastritis Assessment (OLGA) and Operative Link on Gastric Intestinal Metaplasia Assessment (OLGIM) are established classification systems used to evaluate atrophic gastritis and intestinal metaplasia, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We evaluated the association of OLGA and OLGIM scores and the risk of gastric cancer (GC) in only prospective cohort studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Systematic review and meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data sources and methods:<\/jats:title>\n                    <jats:p>We systematically searched four databases for prospective cohorts that evaluated the use of OLGA and OLGIM staging systems in predicting the risk of GC. We primarily compared OLGA\/OLGIM III\u2013IV versus OLGA\/OLGIM 0\u2013II categories and GC events. Pooled risk ratios (RR) and absolute risk differences with their 95% confidence intervals (CIs) were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Eight studies were included (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200912,526). The mean age of the patients ranged from 48.2 to 64.9\u2009years. OLGA III\u2013IV and OLGIM III\u2013IV were associated with the development of GC in comparison to their 0\u2013II categories (RR 32.31, 95% CI 9.14\u2013114.21 and RR 12.38, 95% CI 5.75\u201326.65, respectively). OLGA III\u2013IV and OLGIM III\u2013IV were associated with an increase in the absolute risk of GC of 4% and 5%, respectively. The risk remained significant if we only included countries with high incidence of GC, and was greater if we excluded one study that included mostly patients with autoimmune gastritis. OLGA II and OLGIM II were associated with higher risk of high-grade dysplasia (HGD) and GC in comparison with OLGA 0\u2013I and OLGIM 0\u2013I, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Higher stages in OLGA and OLGIM systems are associated with a significantly increased risk of developing HGD and GC, validating these scoring systems for the assessment of GC risk and the design of endoscopic surveillance programs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial PROSPERO registration:<\/jats:title>\n                    <jats:p>CRD42024565771.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17562848251325461","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T05:54:31Z","timestamp":1742277271000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":36,"title":["OLGA and OLGIM staging systems on the risk assessment of gastric cancer: a systematic review and meta\u2011analysis of prospective cohorts"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2083-1840","authenticated-orcid":false,"given":"Harold","family":"Benites-Go\u00f1i","sequence":"first","affiliation":[{"name":"Unidad de Revisiones Sistem\u00e1ticas y Meta-an\u00e1lisis, Universidad San Ignacio de Loyola, Avenida La Fontana 550, 15024, Lima, Peru"},{"name":"Department of Gastroenterology, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3509-971X","authenticated-orcid":false,"given":"Dacio","family":"Cabrera-Hinojosa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital Nacional Dos de Mayo, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Latorre","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian V.","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Unidad de Revisiones Sistem\u00e1ticas y Meta-an\u00e1lisis, Universidad San Ignacio de Loyola, Lima, Peru"},{"name":"Health Outcomes, Policy and Evidence Synthesis Group, University of Connecticut School of Pharmacy, Storrs, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Uchima","sequence":"additional","affiliation":[{"name":"Endoscopy Unit, Teknon Medical Center, Barcelona, Spain"},{"name":"Endoscopy Unit, Gastroenterology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnoldo","family":"Riquelme","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"},{"name":"Centro para la Prevenci\u00f3n y el Control del C\u00e1ncer, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2014.07.047"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31288-5"},{"issue":"1","key":"e_1_3_4_6_2","first-page":"26","article-title":"Epidemiology of gastric cancer: global trends, risk factors and prevention","volume":"14","author":"Rawla P","year":"2019","unstructured":"Rawla P, Barsouk A. 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