{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T08:22:27Z","timestamp":1767687747266,"version":"3.48.0"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>The vast majority of colorectal cancers (CRCs) are proficient mismatch repair (pMMR) and microsatellite stable, and their immune microenvironment appears as a \u201ccold tumor,\u201d which is not sensitive to single immunotherapy based on immune checkpoint inhibitors (ICIs). The utilization of ICIs in pMMR advanced CRC is still in the exploratory phase. Cutaneous metastasis from colorectal carcinoma is extremely rare, presenting with diverse clinical manifestations, and there is a lack of standard treatment options for such cases. Patients with skin metastasis from CRC usually progress rapidly and are associated with a dismal prognosis. Herein, we report the case of a 66-year-old woman with extensive cutaneous metastasis of pMMR advanced rectal carcinoma. The patient presented to the abdominal oncology clinic with a complaint of erythema on the right lower limb, perineum, and abdominal skin. The patient underwent radical surgery for rectal carcinoma 3\u2009years before the presentation. The histologic examination revealed low-grade squamous cell subepithelial adenocarcinoma. The patient was treated with sintilizumab in combination with fruquintinib, which exhibited remarkable efficacy and improved the patient\u2019s quality of life significantly. Previous cases of cutaneous metastasis of colorectal carcinoma were retrieved to characterize the clinicopathological features. For the rare subset of patients with skin metastasis from CRC, immunotherapy combined with anti-angiogenic targeted therapy may be considered.<\/jats:p>","DOI":"10.1177\/17562848251338673","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T06:13:20Z","timestamp":1746684800000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Partial response to posterior line immunotherapy for more than 15 months in a pMMR patient with cutaneous metastasis of rectal carcinoma: a case report"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9893-3665","authenticated-orcid":false,"given":"Jing-Jing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Abdominal Oncology, Hubei Cancer Hospital, Tongji Medical College, Huazhong"},{"name":"University of Science and Technology, Wuhan, Hubei Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng-Fei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Abdominal Oncology, Hubei Cancer Hospital, Tongji Medical College, Huazhong"},{"name":"University of Science and Technology, Wuhan, Hubei Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Li","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Abdominal Oncology, Hubei Cancer Hospital, Tongji Medical College, Huazhong"},{"name":"University of Science and Technology, No. 116 Zhuodaoquan South Road, Wuhan, Hubei Province 430000, China"},{"name":"Hubei Provincial Clinical Research Center for Colorectal Cancer, Wuhan, Hubei Province, China"},{"name":"Wuhan Clinical Research Center for Colorectal Cancer, Wuhan, Hubei Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"e_1_3_4_2_2","unstructured":"Ferlay J Ervik M Lam F et al. 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Cutaneous metastasis from colorectal cancer: making light on an unusual and misdiagnosed event. Life (Basel) 2021; 11(9): 954.","journal-title":"Life (Basel)"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.7812\/TPP\/15-078"},{"issue":"2","key":"e_1_3_4_12_2","article-title":"Cutaneous metastasis in colorectal cancer: a rare and overlooked phenomenon","volume":"16","author":"Okafor C.","year":"2024","unstructured":"Okafor C. Cutaneous metastasis in colorectal cancer: a rare and overlooked phenomenon. Cureus 2024; 16(2): e53437.","journal-title":"Cureus"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14212420"},{"issue":"1","key":"e_1_3_4_14_2","article-title":"A rare case of cutaneous metastasis of unresectable rectal adenocarcinoma","volume":"16","author":"Akhtar S","year":"2024","unstructured":"Akhtar S, Khan Q, Rehman A, et al. A rare case of cutaneous metastasis of unresectable rectal adenocarcinoma. Cureus 2024; 16(1): e51550.","journal-title":"Cureus"},{"issue":"3","key":"e_1_3_4_15_2","article-title":"Cutaneous limb metastasis of colorectal cancer misdiagnosed as zoster infection","volume":"15","author":"Albandak M","year":"2023","unstructured":"Albandak M, Albandak M, Abdallah J, et al. Cutaneous limb metastasis of colorectal cancer misdiagnosed as zoster infection. Cureus 2023; 15(3): e36621.","journal-title":"Cureus"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20132441"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.4174\/astr.2017.93.5.277"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.4103\/1947-2714.118918"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0126-x"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1500596"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.03296"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-018-0998-z"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000-9604.2019.01.07"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/19420862.2018.1556465"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-019-1066-z"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.851756"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.3_suppl.95"},{"key":"e_1_3_4_28_2","first-page":"7102845","article-title":"Interesting case of skin metastasis in colorectal cancer and review of literature","volume":"2018","author":"Amarjothi J","year":"2018","unstructured":"Amarjothi J, Villalan R, Jeyasudhahar J, et al. Interesting case of skin metastasis in colorectal cancer and review of literature. 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