{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T02:31:41Z","timestamp":1772937101852,"version":"3.50.1"},"reference-count":18,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>In 2023, the diagnostic criteria for gastroesophageal reflux disease (GERD) were updated in the Lyon Consensus 2.0. It is important to investigate the diagnostic accuracy of complementary tests used for GERD diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To determine the diagnostic accuracy of mean nocturnal basal impedance (MNBI) measured by pH-metry in patients with suspected GERD compared to the updated 2023 Lyon Consensus Diagnostic Criteria and to identify the optimal cutoff point for diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Diagnostic test study based on a retrospective cohort of patients with suspected GERD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Diagnosis was confirmed using the updated Lyon criteria as the gold standard. We evaluated sensitivity, specificity, and discriminatory ability via area under the receiver operating characteristic curve (AUC-ROC). The best cutoff point was determined using Liu\u2019s method for MNBI, number of reflux episodes, number of acid reflux episodes, DeMeester score, and bolus exposure time. ROC curves were compared using DeLong\u2019s method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 55 patients were included, with 26 diagnosed positive and 29 negative for GERD. MNBI yielded an AUC-ROC of 0.77 (95% confidence interval (CI): 0.64\u20130.89); at 1590\u2009ohms, sensitivity and specificity were 69.2% and 72.4%, respectively. The DeMeester score demonstrated superior discriminatory ability over MNBI (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.03), with an AUC-ROC of 0.90 (95% CI: 0.80\u20131.00), sensitivity of 92%, and specificity of 93% at a cutoff of 15.6. No significant differences in discriminatory ability were observed when comparing MNBI with other complementary tests (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>MNBI and other complementary tests showed suboptimal characteristics for GERD diagnosis. These tests should be interpreted alongside clinical, endoscopic, and pH-metry findings. The DeMeester score seems promising, but further prospective studies are needed to prove its utility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17562848251340495","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T08:04:33Z","timestamp":1747901073000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Diagnostic accuracy of mean nocturnal basal impedance and other complementary tests for the diagnosis of gastroesophageal reflux disease according to the new Lyon criteria"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6392-7554","authenticated-orcid":false,"given":"Carlos","family":"Lombo-Moreno","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Pontificia Universidad Javeriana, Cra 7 #40\u201362, Bogot\u00e1 110231, Colombia"},{"name":"Gastroenterology Unit, Hospital Universitario San Ignacio, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"La Rotta","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Pontificia Universidad Javeriana, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6506-9485","authenticated-orcid":false,"given":"Manuelita","family":"Pardo-Ortiz","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Pontificia Universidad Javeriana, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fredy Alexander","family":"Avila","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitario San Ignacio, Bogot\u00e1, Colombia"},{"name":"Internal Medicine Department, Pontificia Universidad Javeriana, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul Antonio","family":"Ca\u00f1adas","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitario San Ignacio, Bogot\u00e1, Colombia"},{"name":"Internal Medicine Department, Pontificia Universidad Javeriana, Bogot\u00e1, Colombia"},{"name":"Internal Medicine Department, Hospital Universitario San Ignacio, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5401-0018","authenticated-orcid":false,"given":"\u00d3scar","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Pontificia Universidad Javeriana, Bogot\u00e1, Colombia"},{"name":"Internal Medicine Department, Hospital Universitario San Ignacio, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albis Cecilia","family":"Hani","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitario San Ignacio, Bogot\u00e1, Colombia"},{"name":"Internal Medicine Department, Pontificia Universidad Javeriana, Bogot\u00e1, Colombia"},{"name":"Internal Medicine Department, Hospital Universitario San Ignacio, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-023-15272-z"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00630.x"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00287-w"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2023-330616"},{"key":"e_1_3_4_6_2","article-title":"STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies","volume":"351","author":"Bossuyt PM","year":"2015","unstructured":"Bossuyt PM, Reitsma JB, Bruns DE, et al.; for the STARD Group. STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies. 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Ambulatory 24-h esophageal pH monitoring: normal values, optimal thresholds, specificity, sensitivity, and reproducibility. 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