{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T08:22:32Z","timestamp":1767687752521,"version":"3.48.0"},"reference-count":9,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Improvement in internal hemorrhoids is frequently observed after endoscopic submucosal dissection (ESD) for rectal intraepithelial neoplasia. This study investigated the effectiveness of rectal ESD in the management of internal hemorrhoids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Twenty-three patients who underwent ESD for tumors adjacent to the dentate line and associated with internal hemorrhoids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A single-arm, retrospective multi-center study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The focal improvement (at the scarring area after ESD) and complete improvement rates of hemorrhoids at follow-up colonoscopies were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Most patients (87%) had mild hemorrhoids. The focal and complete improvement rates of hemorrhoids were 83% and 48%, respectively. Complete improvement rates were 75% (3\/4), 42% (5\/12), and 43% (3\/7) for tumors involving \u2a7e1\/2, between 1\/4 and 1\/2, and &lt;1\/4 of the circumference at the dentate line, respectively. No recurrence was observed after initial improvement, with a median observation period of 35\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>ESD may be an effective treatment for internal hemorrhoids.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17562848251355710","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T08:39:23Z","timestamp":1752136763000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of endoscopic submucosal dissection in the management of internal hemorrhoids: a retrospective cohort study"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3646-5796","authenticated-orcid":false,"given":"Hidenori","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hiroshima University Hospital, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8551, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Kuwai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan"},{"name":"Department of Gastroenterology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hiroshima City North Medical Center Asa Citizens Hospital, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Asayama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hiroshima City North Medical Center Asa Citizens Hospital, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Hiraga","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Hiroshima Prefectural Hospital, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Kohno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hiroshima Red Cross Hospital and Atomic-Bomb Survivors Hospital, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzuru","family":"Tamaru","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Kunihiro","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koki","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Miyoshi Central Hospital, Miyoshi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6494-8157","authenticated-orcid":false,"given":"Ken","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Kishida","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6016-4387","authenticated-orcid":false,"given":"Shiro","family":"Oka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.05.051"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.07.002"},{"key":"e_1_3_5_4_2","first-page":"529","article-title":"Safety and efficacy of endoscopic submucosal dissection of rectal tumors extending to the dentate line","volume":"47","author":"Imai K","year":"2015","unstructured":"Imai K, Hotta K, Yamaguchi Y, et al. Safety and efficacy of endoscopic submucosal dissection of rectal tumors extending to the dentate line. Endoscopy 2015; 47: 529\u2013532.","journal-title":"Endoscopy"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i27.6268"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-016-4761-9"},{"key":"e_1_3_5_7_2","volume-title":"Japanese classification of colorectal, appendiceal, and anal carcinoma: third English edition","author":"Japanese Society for Cancer of the Colon and Rectum","year":"2019","unstructured":"Japanese Society for Cancer of the Colon and Rectum. Japanese classification of colorectal, appendiceal, and anal carcinoma: third English edition. Tokyo: Kanehara Co., Ltd, 2019."},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i31.9245"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.23922\/jarc.2022-068"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.2478\/jtim-2020-0036"}],"container-title":["Therapeutic Advances in Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562848251355710","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17562848251355710","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562848251355710","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T08:18:20Z","timestamp":1767687500000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17562848251355710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":9,"alternative-id":["10.1177\/17562848251355710"],"URL":"https:\/\/doi.org\/10.1177\/17562848251355710","relation":{},"ISSN":["1756-2848","1756-2848"],"issn-type":[{"type":"print","value":"1756-2848"},{"type":"electronic","value":"1756-2848"}],"subject":[],"published":{"date-parts":[[2025,7]]},"article-number":"17562848251355710"}}