{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T20:11:45Z","timestamp":1758053505208,"version":"3.44.0"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100004331","name":"Johnson and Johnson","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Inflammatory bowel disease (IBD) develops from a dysregulated immune response influenced by environmental exposures. Radon, a radioactive gas, has known biological effects, but its role in IBD remains unexplored.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Objectives:<\/jats:title>\n            <jats:p>To examine the association between residential radon exposure and the risk and clinical course of IBD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Design:<\/jats:title>\n            <jats:p>A case\u2013control study with 1-year prospective follow-up of cases.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>We included 178 newly diagnosed IBD patients and 178 age- and sex-matched controls in Santiago de Compostela, Spain, from June 2020 to September 2023. Residential radon levels were measured using passive detectors for 3\u2009months. Outcomes included IBD diagnosis, disease extent, hospitalizations, and flares. Logistic regression was used to estimate odds ratios adjusted for age and sex.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              Median residential radon was 144.5\u2009Bq\/m\n              <jats:sup>3<\/jats:sup>\n              in IBD cases and 189.5\u2009Bq\/m\n              <jats:sup>3<\/jats:sup>\n              in controls. Higher radon levels were associated with reduced odds of IBD (OR 0.5 for 100\u2013299 and &gt;299\u2009Bq\/m\n              <jats:sup>3<\/jats:sup>\n              vs 0\u201399\u2009Bq\/m\n              <jats:sup>3<\/jats:sup>\n              ). No significant association was found between radon levels and hospitalizations or flares. Among ulcerative colitis patients, higher radon was linked to more extensive disease.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>Higher residential radon exposure might be inversely associated with IBD risk. However, it does not appear to influence disease progression. Further studies are needed to confirm these findings, since this is the first study on this topic, and chance or selection bias might be present.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1177\/17562848251374190","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T06:16:46Z","timestamp":1757485006000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Indoor radon concentration and risk and severity of inflammatory bowel diseases: a case\u2013control study"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7169-5087","authenticated-orcid":false,"given":"Violeta","family":"Mauriz-Barreiro","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine and Public Health, CRETUS, University of Santiago de Compostela, R\u00faa da Choupana S\/N, Santiago de Compostela 15706, Spain"},{"name":"Clinical University Hospital of Santiago de Compostela, Santiago de Compostela, Spain"},{"name":"Fundacion Instituto de Investigaci\u00f3n Sanitaria of Santiago de Compostela, A Coru\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Ruano-Ravi\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, CRETUS, University of Santiago de Compostela, Santiago de Compostela, Spain"},{"name":"CIBER of Epidemiology and Public Health, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roc\u00edo","family":"Ferreiro-Iglesias","sequence":"additional","affiliation":[{"name":"Clinical University Hospital of Santiago de Compostela, Santiago de Compostela, Spain"},{"name":"Fundacion Instituto de Investigaci\u00f3n Sanitaria of Santiago de Compostela, A Coru\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iria","family":"Bast\u00f3n-Rey","sequence":"additional","affiliation":[{"name":"Clinical University Hospital of Santiago de Compostela, Santiago de Compostela, Spain"},{"name":"Fundacion Instituto de Investigaci\u00f3n Sanitaria of Santiago de Compostela, A Coru\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Calvi\u00f1o-Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Clinical University Hospital of Santiago de Compostela, Santiago de Compostela, Spain"},{"name":"Fundacion Instituto de Investigaci\u00f3n Sanitaria of Santiago de Compostela, A Coru\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Nieto-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Clinical University Hospital of Santiago de Compostela, Santiago de Compostela, Spain"},{"name":"Fundacion Instituto de Investigaci\u00f3n Sanitaria of Santiago de Compostela, A Coru\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sol","family":"Porto-Silva","sequence":"additional","affiliation":[{"name":"Clinical University Hospital of Santiago de Compostela, Santiago de Compostela, Spain"},{"name":"Fundacion Instituto de Investigaci\u00f3n Sanitaria of Santiago de Compostela, A Coru\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xurxo","family":"Mart\u00ednez-Seara","sequence":"additional","affiliation":[{"name":"Clinical University Hospital of Santiago de Compostela, Santiago de Compostela, Spain"},{"name":"Fundacion Instituto de Investigaci\u00f3n Sanitaria of Santiago de Compostela, A Coru\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc\u00eda","family":"Mart\u00edn-Gisbert","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, CRETUS, University of Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8283-3185","authenticated-orcid":false,"given":"J. 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