{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:41:01Z","timestamp":1782301261762,"version":"3.54.5"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province, Youth Science Fund","doi-asserted-by":"publisher","award":["ZR2023QH26"],"award-info":[{"award-number":["ZR2023QH26"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China, Youth Program","doi-asserted-by":"publisher","award":["82401839"],"award-info":[{"award-number":["82401839"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Optimal management of peptic ulcer bleeding remains a clinical challenge.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Objectives:<\/jats:title>\n            <jats:p>To evaluate the efficacy and safety of endoscopic glue injection (EGI) for acute peptic ulcer bleeding.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Design:<\/jats:title>\n            <jats:p>Single-center retrospective study.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>This study (October 2015\u2013December 2024) included adults (\u2a7e18\u2009years) with high-risk peptic ulcer bleeding (Forrest Ia\u2013IIa) treated with EGI using n-butyl \u03b1-cyanoacrylate ester or standard endoscopic treatment (SET) involving contact thermal therapy and hemoclips. The primary endpoint was the rebleeding within 7\u2009days, and the secondary endpoints included rebleeding within 30\u2009days, 30-day all-cause mortality rate, occurrence of adverse events (AEs), and length of hospital stay and intensive care unit (ICU) stay. Risk factors for rebleeding within 7\u2009days were also analyzed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              A total of 148 patients were included (EGI: 57; SET: 91). The rates of rebleeding within 7\u2009days were 8.77% (EGI) versus 20.88% (SET;\n              <jats:italic toggle=\"yes\">p<\/jats:italic>\n              \u2009=\u20090.067), and within 30\u2009days were 8.77% versus 21.98%, respectively (\n              <jats:italic toggle=\"yes\">p<\/jats:italic>\n              \u2009=\u20090.043). The 30-day all-cause mortality rate was 0.0% for EGI versus 1.1% for SET (\n              <jats:italic toggle=\"yes\">p<\/jats:italic>\n              \u2009=\u20091.000). AEs\u2014including Mallory\u2013Weiss syndrome, esophageal blood blister, pulmonary embolism, hemorrhagic shock, cardiovascular or cerebrovascular events, infections, multiple organ failure, and lower limb thrombosis\u2014did not differ significantly between groups (all\n              <jats:italic toggle=\"yes\">p<\/jats:italic>\n              \u2009&gt;\u20090.05). Mean hospital stay was shorter in the EGI group (10.91\u2009\u00b1\u200912.40 vs 15.38\u2009\u00b1\u200910.91\u2009days;\n              <jats:italic toggle=\"yes\">p<\/jats:italic>\n              \u2009=\u20090.002); ICU stay was similar (\n              <jats:italic toggle=\"yes\">p<\/jats:italic>\n              \u2009=\u20090.153). Forrest classification Ia (odds ratio (OR)\u2009=\u20098.294;\n              <jats:italic toggle=\"yes\">p<\/jats:italic>\n              \u2009=\u20090.013) and kidney disease (OR\u2009=\u200924.257;\n              <jats:italic toggle=\"yes\">p<\/jats:italic>\n              \u2009=\u20090.003) were independent risk factors for rebleeding within 7\u2009days.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>EGI may be an effective and safe treatment for acute peptic ulcer bleeding, significantly reducing 30-day rebleeding and shortening hospital stay compared with SET. Clinicians should exercise heightened vigilance and consider more intensive monitoring or preventive strategies for patients with Forrest classification Ia ulcers or underlying kidney disease, who are at increased risk of early rebleeding.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1177\/17562848251383778","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T10:19:41Z","timestamp":1760437181000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and safety of endoscopic glue injection in acute peptic ulcer bleeding"],"prefix":"10.1177","volume":"18","author":[{"given":"XingSi","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ShiDong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JunBo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Shinan District, Qingdao, Shandong Province 266003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6515-1780","authenticated-orcid":false,"given":"YuShuang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Shinan District, Qingdao, Shandong Province 266003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"e_1_3_4_2_2","first-page":"1","article-title":"National consensus on management of peptic ulcer bleeding in Denmark 2014","volume":"61","author":"Laursen SB","year":"2014","unstructured":"Laursen SB, J\u00f8rgensen HS, Schaffalitzky de, Muckadell OB. 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