{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:19:17Z","timestamp":1789625957038,"version":"build-2803163510"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Patients with inflammatory bowel disease (IBD) are at heightened risk of infection for several reasons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To evaluate the factors predisposing IBD patients to gastrointestinal (GI) infections, the elements influencing the severity of these infections and the likelihood of hospitalization, and the impact of GI bacterial infections on the progression of IBD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Retrospective, single-center, case-control study of IBD patients with GI infection and matched controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Patients with ulcerative colitis (UC) or Crohn\u2019s disease who tested positive for\n                      <jats:italic toggle=\"yes\">Campylobacter<\/jats:italic>\n                      spp.,\n                      <jats:italic toggle=\"yes\">Yersinia<\/jats:italic>\n                      spp.,\n                      <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                      spp., or\n                      <jats:italic toggle=\"yes\">enterohemorrhagic Escherichia coli<\/jats:italic>\n                      were enrolled. Clostridioides\n                      <jats:italic toggle=\"yes\">difficile<\/jats:italic>\n                      was excluded due to its distinct epidemiology. For each patient with a GI bacterial infection, a control patient with IBD but without the infection was matched by sex and proximity in calendar age. Data were collected from electronic patient records spanning from January 2008 to June 2023. Various risk factors for medical consultations and hospitalizations due to GI bacterial infections were evaluated. Fisher\u2019s exact test and logistic regression were used to assess the associations between GI infections and clinical outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of the 5194 IBD patients in the IBD registry, 123 patients had a confirmed GI infection, the majority having UC (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200979, 64%). Patients who experienced GI infection had a higher likelihood of experiencing an IBD flare within 1\u20136\u2009months post-infection, often requiring intensification of medication, than the control group. However, such factors as age, IBD phenotype, disease activity, comorbidities, IBD pharmacological treatment, and prior travel to countries with lower hygiene standards did not increase the risk of severe bacterial infection or the likelihood of requiring hospitalization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our study indicates that IBD patients diagnosed with GI infections may be at elevated risk of experiencing an IBD flare within 1\u20136\u2009months post-infection, often necessitating the intensification of their pharmacological treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17562848251386318","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T06:44:30Z","timestamp":1761201870000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Gastrointestinal bacterial infections precede disease activation and treatment intensification in patients with inflammatory bowel disease"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2298-857X","authenticated-orcid":false,"given":"Merit","family":"Kase","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Rehabilitation, Helsinki University Hospital and University of Helsinki, P.O. 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