{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:13:52Z","timestamp":1780485232681,"version":"3.54.1"},"reference-count":43,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Noncommunicable Chronic DiseasesNational Science and Technology Major Project","award":["No.2023ZD0500904"],"award-info":[{"award-number":["No.2023ZD0500904"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Needle-based confocal laser endomicroscopy (nCLE) can accurately identify the pathological types of pancreatic cystic lesions (PCLs), but there are no reports of real-time intraoperative guidance for lauromacrogol ablation (LA) therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aimed to assess the diagnostic accuracy and safety of nCLE in identifying the candidates for LA in the same session as endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Prospective study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We performed a prospective study of patients with PCL who underwent EUS-FNA and nCLE at the First Medical Center of Chinese PLA General Hospital between February 2024 and June 2025. The diagnostic performance of nCLE in intraoperatively differentiating concomitant ablation-eligible lesions (CAELs) from concomitant ablation-ineligible lesions (CAILs) was evaluated and compared with that of EUS morphology and the cyst fluid string sign.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 29 patients were enrolled in the study, and the mean size of the cyst was 34.1\u2009\u00b1\u200912.5\u2009mm. The mean duration of EUS-nCLE was 4.61\u2009min. EUS-nCLE identified CAELs with 94% sensitivity, 77% specificity, and 86% accuracy. The diagnostic accuracy of nCLE was superior to that of EUS morphology and the string sign (86% vs 66%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.039). Postprocedural acute pancreatitis occurred in 2 of 29 patients (6.9%), and all episodes were mild according to the revised Atlanta classification.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Confocal laser endomicroscopy demonstrates favorable real-time diagnostic performance for PCLs, allowing accurate assessment of the suitability for ablation during puncture and thereby avoiding the need for a repeat procedure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17562848261422841","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T02:30:16Z","timestamp":1771209016000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Real-time guidance of lauromacrogol ablation for pancreatic cystic lesions using confocal laser endomicroscopy"],"prefix":"10.1177","volume":"19","author":[{"given":"Xinwei","family":"Hao","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuxue","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2013-9881","authenticated-orcid":false,"given":"Fang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longsong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Ru","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4506-7877","authenticated-orcid":false,"given":"Enqiang","family":"Linghu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawei","family":"Bi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, No. 28, Fuxing Road, Beijing 100853, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8875-5544","authenticated-orcid":false,"given":"Ningli","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, No. 28, Fuxing Road, Beijing 100853, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,15]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2019.09.037"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2023.12.009"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.03.1525"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/EUS-D-20-00231"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.06.010"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-0732-5356"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1344714"},{"issue":"9","key":"e_1_3_4_10_2","article-title":"Position statement on EUS-guided ablation of pancreatic cystic neoplasms from an international expert panel","volume":"7","author":"Teoh AY","year":"2019","unstructured":"Teoh AY, Seo DW, Brugge W, et al. Position statement on EUS-guided ablation of pancreatic cystic neoplasms from an international expert panel. Endosc Int Open 2019; 7(9): E1064\u2013E1077.","journal-title":"Endosc Int Open"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0195-x"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2024.02.041"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2021.01.030"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.4103\/2303-9027.170423"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1391484"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2023.07.019"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2014.10.025"},{"issue":"1","key":"e_1_3_4_18_2","first-page":"26","article-title":"A novel approach to the diagnosis of pancreatic serous cystadenoma: needle-based confocal laser endomicroscopy","volume":"47","author":"Napol\u00e9on B","year":"2015","unstructured":"Napol\u00e9on B, Lemaistre AI, Pujol B, et al. A novel approach to the diagnosis of pancreatic serous cystadenoma: needle-based confocal laser endomicroscopy. Endoscopy 2015; 47(1): 26\u201332.","journal-title":"Endoscopy"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.4103\/eus.eus_35_20"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2019.09.014"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2024.24124"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.03.021"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302779"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-020-08166-3"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002088"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.4103\/EUS-D-20-00172"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2025.03.851"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2023.05.049"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.4103\/EUS-D-21-00178"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2023.12.008"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i23.3213"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15092627"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(05)00320-2"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001297"},{"key":"e_1_3_4_35_2","article-title":"Endoscopic ultrasound-guided radiofrequency ablation for treatment of pancreatic neuroendocrine tumors: multicenter prospective study","volume":"13","author":"Rizzatti G","year":"2025","unstructured":"Rizzatti G, Napol\u00e9on B, Caillol F, et al. Endoscopic ultrasound-guided radiofrequency ablation for treatment of pancreatic neuroendocrine tumors: multicenter prospective study. Endosc Int Open 2025; 13: a26895949.","journal-title":"Endosc Int Open"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaf571"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-1250-7786"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-0824-7067"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diii.2016.08.005"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.03.002"},{"issue":"11","key":"e_1_3_4_41_2","article-title":"Confocal endomicroscopy for evaluation of pancreatic cystic lesions: a systematic review and international Delphi consensus report","volume":"8","author":"Napoleon B","year":"2020","unstructured":"Napoleon B, Krishna SG, Marco B, et al. Confocal endomicroscopy for evaluation of pancreatic cystic lesions: a systematic review and international Delphi consensus report. Endosc Int Open 2020; 8(11): E1566\u2013E1581.","journal-title":"Endosc Int Open"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2024.11.023"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.08.009"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.03.041"}],"container-title":["Therapeutic Advances in Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562848261422841","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17562848261422841","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562848261422841","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:14:31Z","timestamp":1771503271000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17562848261422841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":43,"alternative-id":["10.1177\/17562848261422841"],"URL":"https:\/\/doi.org\/10.1177\/17562848261422841","relation":{},"ISSN":["1756-2848","1756-2848"],"issn-type":[{"value":"1756-2848","type":"print"},{"value":"1756-2848","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"article-number":"17562848261422841"}}