{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:06:19Z","timestamp":1787843179736,"version":"build-2784847793"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Zhongda Hospital Affiliated to Southeast University, Jiangsu Province HighLevel Hospital Construction Funds","award":["YKK24268"],"award-info":[{"award-number":["YKK24268"]}]},{"name":"Nanjing Science and Technology Development Program","award":["202305041"],"award-info":[{"award-number":["202305041"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404088"],"award-info":[{"award-number":["82404088"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Laparoscopic appendectomy (LA) is the conventional treatment for chronic appendicitis. Endoscopic direct-vision appendicitis therapy (EDAT) has emerged as a minimally invasive, organ-preserving alternative.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To compare the efficacy and safety of EDAT versus LA in chronic appendicitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Multicenter retrospective cohort study with propensity score matching (PSM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This multicenter retrospective cohort study was conducted in China between January 2019 and February 2024. PSM was performed to minimize selection bias. A total of 186 patients with chronic appendicitis were included, including 63 who received EDAT and 123 who underwent LA. The primary outcome was the clinical success rate. The secondary outcomes included the technical success rate, duration of hospitalization, adverse event rate, and recurrence rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Compared with LA, EDAT showed comparable clinical success (95.2% vs 100%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.068) and technical success rates (96.8% vs 98.4%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.877). EDAT reduced the duration of hospitalization (median 2 vs 3\u2009days,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and short- and long-term overall adverse event rates (6.4% vs 45.5% and 7.9% vs 21.1%, respectively;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.022). At 6, 24, and 48\u2009h postoperatively, the EDAT group had a greater proportion of patients with no pain or mild pain than the LA group did (68.3% vs 40.7% and 90.5% vs 66.7% and 98.4% vs 74.8%, respectively; all\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). After the 1-year follow-up, the calculated recurrence rate did not differ between the groups (4.8% vs 0%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.068).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Compared with LA, EDAT is a safe, effective, organ-preserving alternative technique for chronic appendicitis, offering a shorter recovery time, reduced adverse event rates, and a low recurrence rate observed during follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17562848261422862","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:46:46Z","timestamp":1771487206000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Digital cholangioscope-assisted endoscopic direct-vision appendicitis therapy versus laparoscopic appendectomy for chronic appendicitis: a multicenter retrospective cohort study"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2411-6935","authenticated-orcid":false,"given":"Lu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Zhongda Hospital Southeast University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadong","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhongda Hospital Southeast University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Liangjiang Hospital Southeast University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhongda Hospital Southeast University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9015-9984","authenticated-orcid":false,"given":"Qin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhongda Hospital Southeast University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1726-3686","authenticated-orcid":false,"given":"Lihua","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhongda Hospital Southeast University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhongda Hospital Southeast University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaizhe","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Medicine, Southeast University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Medicine, Southeast University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Affiliated Changshu Hospital of Nantong University, Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4977-8801","authenticated-orcid":false,"given":"Ruihua","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhongda Hospital Southeast University, Nanjing 210009, China Department of Gastroenterology, Liangjiang Hospital Southeast University, Nanjing 211800, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"e_1_3_4_2_2","article-title":"An imitator within: a case of appendiceal neuroma masquerading as chronic appendicitis","volume":"17","author":"Siew ZY","year":"2025","unstructured":"Siew ZY, Ong GK, Khoo CT, et al An imitator within: a case of appendiceal neuroma masquerading as chronic appendicitis. Cureus 2025; 17: e83986.","journal-title":"Cureus"},{"key":"e_1_3_4_3_2","article-title":"A 61-year-old male with chronic appendicitis: a case report","volume":"14","author":"Almansouri O","year":"2022","unstructured":"Almansouri O, Algethmi AM, Qutub M, et al A 61-year-old male with chronic appendicitis: a case report. Cureus 2022; 14: e32130.","journal-title":"Cureus"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12821"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000322"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2018.10.009"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-024-11339-z"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000003428"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02108-6"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-025-11797-z"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2012.05.029"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-1737-6381"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-014-3750-0"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4245-8"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005576"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2024.04.010"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-69943-x"},{"key":"e_1_3_4_18_2","first-page":"814","article-title":"Efficacy and safety of endoscopic direct-vision appendicitis therapy in patients with acute appendicitis","volume":"105","author":"Li MY","year":"2025","unstructured":"Li MY, Liang Y, Feng YD, et al Efficacy and safety of endoscopic direct-vision appendicitis therapy in patients with acute appendicitis. Zhonghua Yi Xue Za Zhi 2025; 105: 814\u2013819.","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2014320"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000003118"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-1490-0434"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-024-08795-x"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-024-11112-2"},{"key":"e_1_3_4_25_2","first-page":"814","article-title":"[Efficacy and safety of endoscopic direct-vision appendicitis therapy in patients with acute appendicitis]","volume":"105","author":"Li MY","year":"2025","unstructured":"Li MY, Liang Y, Feng YD, et al [Efficacy and safety of endoscopic direct-vision appendicitis therapy in patients with acute appendicitis]. Zhonghua Yi Xue Za Zhi 2025; 105: 814\u2013819.","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_3_4_26_2","article-title":"Endoscopic direct-vision appendicitis therapy for the treatment of chronic appendicitis with multiple appendicoliths","volume":"57","author":"Ren LH","year":"2025","unstructured":"Ren LH, Ding Y, Li Y, et al Endoscopic direct-vision appendicitis therapy for the treatment of chronic appendicitis with multiple appendicoliths. Endoscopy 2025; 57: E617\u2013E618.","journal-title":"Endoscopy"}],"container-title":["Therapeutic Advances in Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562848261422862","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17562848261422862","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562848261422862","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T18:39:51Z","timestamp":1773254391000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17562848261422862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,18]]},"references-count":25,"alternative-id":["10.1177\/17562848261422862"],"URL":"https:\/\/doi.org\/10.1177\/17562848261422862","relation":{},"ISSN":["1756-2848","1756-2848"],"issn-type":[{"value":"1756-2848","type":"print"},{"value":"1756-2848","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,18]]},"article-number":"17562848261422862"}}