{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:27:30Z","timestamp":1790263650232,"version":"4.1.0"},"reference-count":49,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The degree of coincidence and interaction between primary biliary cholangitis (PBC) on the one hand and metabolic syndrome (MetS) or metabolic dysfunction-associated steatotic liver disease (MASLD) on the other is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The aim of the study was to evaluate the associations between MASLD\/MetS and PBC, with the focus on liver fibrosis (F).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Cross-sectional observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Cross-sectional observational study recruited consecutive patients treated for PBC prospectively from a single tertiary center. The control group was sampled, matched for age and sex, from the general population obtained from nation wide SIRIUS database, which aims to screen the general population for liver disease. Liver stiffness as a surrogate marker of liver fibrosis was the primary outcome, while achieving complete biochemical response (CBR) was a secondary outcome of our research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Prevalence of MASLD was 42.3% in the PBC group and 41.9% in the control group (NS). Prevalence of MetS was 38.9% in PBC and 60.7% in the control group (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Advanced liver fibrosis was present significantly more often in the PBC group (21.5%), even after stratification by CBR (9.8%), than in age and sex matched general population (2%;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.003). MetS (odds ratio (OR) 4.561, 95% confidence interval (CI): 1.852\u201311.398) and the number of fulfilled MetS criteria (1.901, 95% CI: 1.239\u20132.915), but not MASLD (OR 3.956, 95% CI: 0.730\u201321.422) were associated with advanced fibrosis. Out of individual MetS criteria hyperglycemia\/diabetes mellitus had the strongest association with advanced fibrosis, followed by high-density lipoprotein cholesterol criterion. Neither MASLD nor MetS was associated with CBR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Patients with PBC appear to have a lower prevalence of MetS than age and sex matched general population, despite the same prevalence of MASLD in both groups. MetS but not MASLD was associated with the presence of advanced fibrosis in patients with PBC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17562848261428810","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T18:27:51Z","timestamp":1773253671000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Metabolic syndrome and its individual components but not MASLD are associated with advanced fibrosis in primary biliary cholangitis"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2448-6757","authenticated-orcid":false,"given":"Sylvia","family":"Drazilova","sequence":"first","affiliation":[{"name":"2nd Department of Internal Medicine, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Kosice, Slovakia"},{"name":"2nd Department of Internal Medicine, Louis Pasteur University Hospital, Kosice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Koky","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Kosice, Slovakia"},{"name":"2nd Department of Internal Medicine, Louis Pasteur University Hospital, Kosice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3329-3968","authenticated-orcid":false,"given":"Martin","family":"Janicko","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Kosice, Slovakia"},{"name":"2nd Department of Internal Medicine, Louis Pasteur University Hospital, Kosice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Brenisin","sequence":"additional","affiliation":[{"name":"Department of Pathological Physiology, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Kosice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Marekova","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Kosice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Spakova","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Kosice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslava","family":"Rabajdova","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Kosice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Rasiova","sequence":"additional","affiliation":[{"name":"Department of Angiology, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Kosice, Slovakia"},{"name":"Department of Angiology, East Slovakian Institute of Cardiovascular Diseases, a.s., Kosice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Barbierik Vachalcova","sequence":"additional","affiliation":[{"name":"1st Department of Cardiology, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Kosice, Slovakia"},{"name":"1st Department of Cardiology, East Slovakian Institute of Cardiovascular Diseases, a.s., Kosice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Pella","sequence":"additional","affiliation":[{"name":"1st Department of Cardiology, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Kosice, Slovakia"},{"name":"1st Department of Cardiology, East Slovakian Institute of Cardiovascular Diseases, a.s., Kosice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Macej","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Kosice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slavomira","family":"Komarova","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Kosice, Slovakia"},{"name":"2nd Department of Internal Medicine, Louis Pasteur University Hospital, Kosice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6169-9984","authenticated-orcid":false,"given":"Peter","family":"Jarcuska","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Trieda SNP 1, Kosice 040 11, Slovaki"},{"name":"2nd Department of Internal Medicine, Louis Pasteur University Hospital, Kosice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.022"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32117"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9151525"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03172.x"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1586\/erm.11.82"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.596"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.4.553"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00038-020-01391-6"},{"key":"e_1_3_4_10_2","article-title":"The treatment of primary biliary cholangitis: from shadow to light","volume":"17","author":"Sylvia D","year":"2024","unstructured":"Sylvia D, Tomas K, Marian M, et al. The treatment of primary biliary cholangitis: from shadow to light. Therap Adv Gastroenterol 2024; 17: 17562848241265782.","journal-title":"Therap Adv Gastroenterol"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11060495"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192644"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67402-8"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2013.09.006"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000140677.20606.0E"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000443743"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-3902-y"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.04.031"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(23)02372-3"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25599"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1509840"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2024.01.044"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.18134"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/jcag\/gwad061.293"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-010-0249-x"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2023.100898"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-021-01974-4"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-315259"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.21101\/cejph.a4968"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2018-101124"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(85)90642-0"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840150518"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840170408"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61933-4"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-012-0162-9"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000029"},{"key":"e_1_3_4_38_2","article-title":"Metabolic syndrome prevalence and its risk factors among adults in China: a nationally representative cross-sectional study","volume":"13","author":"Li Y","year":"2018","unstructured":"Li Y, Zhao L, Yu D, et al. Metabolic syndrome prevalence and its risk factors among adults in China: a nationally representative cross-sectional study. PLoS One 2018; 13: e0199293.","journal-title":"PLoS One"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lansea.2023.100220"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2024.10.012"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010214"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.11.010"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-2048"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.06.021"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.16666"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13644"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.04.001"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-025-04138-w"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000557"}],"container-title":["Therapeutic Advances in Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562848261428810","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17562848261428810","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562848261428810","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T19:46:23Z","timestamp":1773344783000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17562848261428810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":49,"alternative-id":["10.1177\/17562848261428810"],"URL":"https:\/\/doi.org\/10.1177\/17562848261428810","relation":{},"ISSN":["1756-2848","1756-2848"],"issn-type":[{"value":"1756-2848","type":"print"},{"value":"1756-2848","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"article-number":"17562848261428810"}}