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One way to keep patient waiting time acceptable could be to introduce alternative diagnostic modalities. Colon capsule endoscopy has been proven to have a high diagnostic accuracy, yet the re-investigation rates reported are too high. Faecal haemoglobin concentration may offer a valid measure for triaging patients between diagnostic modalities, due to its association with colonic pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate the re-investigation rate and risk classification in complete colon capsule endoscopies in a screening population stratified by faecal haemoglobin concentration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Cross-sectional analyses of a data set derived from the intervention arm of a large randomised controlled trial, CareForColon2015, conducted in the Region of Southern Denmark between August 2020 and December 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Complete colon capsule endoscopy investigations were identified, and the proportions of investigations leading to re-investigation by colonoscopy were calculated, stratified by faecal haemoglobin concentration. Further, the odds of re-investigation were estimated by logistic regression models and the odds of increased risk classification by ordinal regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The re-investigation rate was 58.6% in 1413 complete colon capsule endoscopies out of 2030 procedures. There were no significant differences (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.312) in re-investigation rates between faecal haemoglobin concentration subgroups with 58.2%, 61.1% and 62.7% in the groups of 100\u2013249, 250\u2013499 and &gt;499\u2009ng hb\/mL buffer, respectively. The odds of referral for re-investigation did not differ significantly either. The odds of increased risk classification (i.e. higher than level one) was 1.17 (CI 95% 0.92; 1.49,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.211) for concentrations between 250 and 499\u2009ng hb\/mL buffer, and 1.40 (CI 95% 1.12; 1.77,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.003) for concentrations above 499\u2009ng hb\/mL buffer, compared to 100\u2013249\u2009ng hb\/mL buffer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Faecal haemoglobin concentration did not prove to be a stand-alone selection parameter for diagnostic modality in a faecal immunochemical test-positive colorectal cancer screening population, although it was significantly associated with an increased risk classification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17562848261434425","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T01:37:12Z","timestamp":1774834632000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Re-investigation rate following colon capsule endoscopy stratified by faecal haemoglobin concentration in a screening population"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8263-2989","authenticated-orcid":false,"given":"Ulrik","family":"Deding","sequence":"first","affiliation":[{"name":"Department of Surgery, Odense University Hospital, baag\u00f8es all\u00e9 15, Svendborg 5700, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7643-2350","authenticated-orcid":false,"given":"Benedicte","family":"Schelde-Olesen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Odense University Hospital, Svendborg, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bj\u00f8rsum-Meyer","sequence":"additional","affiliation":[{"name":"Department of Surgery, Odense University Hospital, Svendborg, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse","family":"Kaalby","sequence":"additional","affiliation":[{"name":"Department of Surgery, Odense University Hospital, Svendborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issam","family":"Al-Najami","sequence":"additional","affiliation":[{"name":"Department of Surgery, Odense University Hospital, Svendborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasios","family":"Koulaouzidis","sequence":"additional","affiliation":[{"name":"Department of Surgery, Odense University Hospital, Svendborg, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5097-9283","authenticated-orcid":false,"given":"Morten","family":"Kobaek-Larsen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Odense University Hospital, Svendborg, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0300-5766","authenticated-orcid":false,"given":"Gunnar","family":"Baatrup","sequence":"additional","affiliation":[{"name":"Department of Surgery, Odense University Hospital, Svendborg, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,29]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/codi.16029"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-020-07413-4"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-020-01717-4"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13965"},{"key":"e_1_3_4_6_2","article-title":"Adenoma detection rate is enough to assess endoscopist performance: a population-based observational study of FIT-positive colonoscopies","volume":"10","author":"Denis B","year":"2022","unstructured":"Denis B, Gendre I, Tuzin N, et al. 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