{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T14:20:44Z","timestamp":1775053244744,"version":"3.50.1"},"reference-count":19,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003122","name":"Ferring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003122","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003053","name":"alberta health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007582","name":"alberta health services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007582","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Corticosteroids induce remission in ulcerative colitis (UC) but are associated with adverse effects, including prednisone \u2a7e20\u2009mg\/day associated with serious COVID-19 outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To evaluate the risk of rescue prednisone use following budesonide multimatrix system (MMX) initiation in newly diagnosed individuals with UC before and during the COVID-19 pandemic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Population-based cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a population-based study in Alberta, Canada, identifying adults with incident UC (2018\u20132022). Courses of budesonide MMX were examined for treatment failure, defined as prednisone rescue or inflammatory bowel disease-specific hospitalization within 90\u2009days. Outcomes were compared between prepandemic (before April 2020) and pandemic periods using Cox proportional hazards models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among 269 dispensings of budesonide MMX (38 with multiple courses), 30.5% required rescue prednisone and 6.7% resulted in hospitalization. Budesonide MMX dispensing declined during the pandemic wherein, the hazard of prednisone rescue increased (HR 1.64; 95% CI: 1.01\u20132.67).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Budesonide MMX was prescribed less frequently during the COVID-19 pandemic, with increased treatment failure, underscoring pandemic-related disruptions in UC management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17562848261434442","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T11:05:50Z","timestamp":1774868750000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Increased failure of budesonide MMX for ulcerative colitis during the COVID-19 pandemic: a population-based study"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0675-7226","authenticated-orcid":false,"given":"Stephanie","family":"Coward","sequence":"first","affiliation":[{"name":"Inflammatory Bowel Disease Clinic, Department of Medicine, University of Calgary, Calgary, AB, Canada"},{"name":"Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3400-7214","authenticated-orcid":false,"given":"Karen J. B.","family":"Martins","sequence":"additional","affiliation":[{"name":"Real World Evidence Unit, University of Alberta, Edmonton, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8611-1056","authenticated-orcid":false,"given":"Scott","family":"Klarenbach","sequence":"additional","affiliation":[{"name":"Real World Evidence Unit, University of Alberta, Edmonton, AB, Canada"},{"name":"Faculty of Medicine and Dentistry, Department of Medicine, University of Alberta, Edmonton, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6897-8668","authenticated-orcid":false,"given":"Lawrence P.","family":"Richer","sequence":"additional","affiliation":[{"name":"Real World Evidence Unit, University of Alberta, Edmonton, AB, Canada"},{"name":"Faculty of Medicine and Dentistry, College of Health Sciences, University of Alberta, Edmonton, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4698-9948","authenticated-orcid":false,"given":"Christopher","family":"Ma","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Clinic, Department of Medicine, University of Calgary, Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5247-940X","authenticated-orcid":false,"given":"Remo","family":"Panaccione","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Clinic, Department of Medicine, University of Calgary, Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1551-9054","authenticated-orcid":false,"given":"Cynthia H.","family":"Seow","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Clinic, Department of Medicine, University of Calgary, Calgary, AB, Canada"},{"name":"Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Kroeker","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, University of Alberta, Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5314-4452","authenticated-orcid":false,"given":"Frank","family":"Hoentjen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, University of Alberta, Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura E.","family":"Targownik","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2719-0556","authenticated-orcid":false,"given":"Gilaad G.","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Clinic, Department of Medicine, University of Calgary, 3D03-18, 3280 Hospital Dr. NW, Calgary, AB T2N 4Z6, Canada"},{"name":"Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2026.01.009"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001220"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.15389"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjaa053"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.09.011"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izab339"},{"key":"e_1_3_4_8_2","article-title":"Crohn\u2019s and colitis Canada\u2019s 2021 impact of COVID-19 and inflammatory bowel disease in Canada: executive summary","volume":"4","author":"Kuenzig EM","year":"2021","unstructured":"Kuenzig EM, Windsor JW, Barrett L, et al. 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