{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:45:39Z","timestamp":1791773139298,"version":"4.3.4"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270623"],"award-info":[{"award-number":["82270623"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Endoscopic variceal treatment (EVT) in cirrhotic patients carries a risk of periprocedural bleeding, making anticoagulation management challenging in those with acute portal vein thrombosis (PVT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The first randomized controlled trial to evaluate the safety and efficacy of continuous versus intermittent anticoagulation during EVT in cirrhotic patients with acute PVT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this trial, cirrhotic patients with acute PVT and esophageal varices requiring EVT were assigned to either a continuous or intermittent anticoagulation group. In the continuous anticoagulation group, anticoagulation began immediately after PVT diagnosis and continued during EVT. In the intermittent group, anticoagulation was resumed 1\u2009week post-procedurally. Incidences of post-procedural bleeding and hepatic decompensation events were observed during a 1-year follow-up period. Potential confounders were adjusted for using multivariable binary logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among 120 enrolled patients, 112 were analyzed (continuous anticoagulation group,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200955; intermittent anticoagulation group,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200957). The rate of early rebleeding within 6\u2009weeks did not differ between groups (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&gt;\u20090.99). However, continuous anticoagulation significantly reduced the incidence of late rebleeding (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.037) and all-cause bleeding (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.020). The cumulative incidences of late rebleeding (hazard ratio (HR)\u2009=\u20090.386, 95% confidence interval (CI): 0.150\u20130.994; log-rank\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.041) and all-cause bleeding (HR\u2009=\u20090.396, 95% CI: 0.173\u20130.904; log-rank\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.023) were significantly lower in the continuous anticoagulation group. The continuous anticoagulation group had significantly lower incidences of hepatic decompensation events (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.006), and ascites (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.015). After adjustment for liver function, indications for EVT, and history of splenectomy, continuous anticoagulation remained significantly associated with superior outcomes compared with intermittent anticoagulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Continuous anticoagulation during EVT in cirrhotic patients with acute PVT is safe and does not increase early rebleeding risk. It significantly reduces late and overall bleeding events and may improve long-term outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration:<\/jats:title>\n                    <jats:p>Chinese Clinical Trial Registry, ChiCTR1800017430.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17562848261439217","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T07:06:33Z","timestamp":1776409593000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Continuous versus intermittent anticoagulation during endoscopic treatment of esophageal varices in cirrhosis: a randomized controlled trial"],"prefix":"10.1177","volume":"19","author":[{"given":"Yingying","family":"He","sequence":"first","affiliation":[{"name":"Key Laboratory of Digestive Diseases of Anhui Province, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Digestive Diseases of Anhui Province, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Digestive Diseases of Anhui Province, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Digestive Diseases of Anhui Province, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxian","family":"Kuai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Digestive Diseases of Anhui Province, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchuan","family":"Bai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Digestive Diseases of Anhui Province, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuecan","family":"Mei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Digestive Diseases of Anhui Province, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei, Anhui Province 230022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3273-5760","authenticated-orcid":false,"given":"Derun","family":"Kong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Digestive Diseases of Anhui Province, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei, Anhui Province 230022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.11.004"},{"key":"e_1_3_4_3_2","first-page":"7556408","article-title":"Analysis of complications and risk factors other than bleeding before and after endoscopic treatment of esophagogastric variceal bleeding in patients with liver cirrhosis","volume":"2023","author":"Duan X","year":"2023","unstructured":"Duan X, He X, Yan H, et al. 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