{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T14:14:40Z","timestamp":1778076880051,"version":"3.51.4"},"reference-count":78,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100012131","name":"department of science and technology of liaoning province","doi-asserted-by":"publisher","award":["2023JH2\/101700099"],"award-info":[{"award-number":["2023JH2\/101700099"]}],"id":[{"id":"10.13039\/501100012131","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Independent Research Funding of General Hospital of Northern Theater Command","award":["ZZKY2024018"],"award-info":[{"award-number":["ZZKY2024018"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"\n Background:<\/jats:title>\n \n Multiple meta-analyses have evaluated the effect of\n Helicobacter pylori<\/jats:italic>\n (\n H. pylori<\/jats:italic>\n ) infection on the risk of inflammatory bowel disease (IBD), but their findings remain inconsistent.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives:<\/jats:title>\n \n To critically assess the existing meta-analyses regarding the effect of\n H. pylori<\/jats:italic>\n infection on the risk of IBD.\n <\/jats:p>\n <\/jats:sec>\n \n Data sources and methods:<\/jats:title>\n \n We systematically searched four electronic databases and manually screened the reference lists of relevant articles. A Measurement Tool to Assess systematic Reviews 2 (AMSTAR-2), Grade of Recommendation, Assessment, Development, and Evaluation (GRADE), and Graphical Representation of Overlap for OVErviews (GROOVE) tools were used to assess the methodological quality, evidence quality, and the overall overlap of primary studies among the included meta-analyses, respectively. A second-order meta-analysis was performed on primary studies derived from the included meta-analyses with very high overlap to explore the association of\n H. pylori<\/jats:italic>\n infection with IBD risk and identify the potential influencing factors. Risk ratios (RRs) were pooled.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Twelve meta-analyses encompassing 55 primary studies were included. The methodological quality was very low to low. The evidence quality was very low to high. Moderate- to high-quality evidence suggested that\n H. pylori<\/jats:italic>\n virulence factors and antibiotic exposure influenced the association of\n H. pylori<\/jats:italic>\n infection with IBD. The overall overlap of primary studies among the included meta-analyses was very high. A second-order meta-analysis demonstrated a negative association of\n H. pylori<\/jats:italic>\n infection with any type of IBD (RR: 0.60), Crohn\u2019s disease (RR: 0.53), ulcerative colitis (RR: 0.67), and IBD-unclassified (RR: 0.73). Subgroup analyses demonstrated that both IBD subtypes (\n P<\/jats:italic>\n interaction<\/jats:sub>\n \u2009<\u20090.01), regions (\n P<\/jats:italic>\n interaction<\/jats:sub>\n \u2009<\u20090.01), and study designs (\n P<\/jats:italic>\n interaction<\/jats:sub>\n \u2009=\u20090.05) significantly influenced this association. Sensitivity analyses indicated that the results were robust across IBD subtypes and regions, but not across the study designs.\n <\/jats:p>\n <\/jats:sec>\n \n Discussion:<\/jats:title>\n \n H. pylori<\/jats:italic>\n infection seems to exhibit a protective effect against the risk of IBD. This association may be influenced by IBD subtypes, regions,\n H. pylori<\/jats:italic>\n virulence factors, and antibiotic exposure.\n <\/jats:p>\n <\/jats:sec>\n \n Design:<\/jats:title>\n This is an umbrella review.<\/jats:p>\n <\/jats:sec>\n \n Registration:<\/jats:title>\n The protocol was prospectively registered with the PROSPERO database (CRD42024559958).<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/17562848261444293","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:24:01Z","timestamp":1777886641000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of\n Helicobacter pylori<\/i>\n infection on the risk of inflammatory bowel disease: an umbrella review and second-order meta-analysis"],"prefix":"10.1177","volume":"19","author":[{"given":"Xiaomin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, General Hospital of Northern Theater Command (Teaching Hospital of Dalian Medical University), Shenyang, China"},{"name":"Postgraduate College, Dalian Medical University, Dalian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haonan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, General Hospital of Northern Theater Command (Teaching Hospital of Dalian Medical University), Shenyang, China"},{"name":"Department of Life Sciences and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honglu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, General Hospital of Northern Theater Command (Teaching Hospital of Dalian Medical University), Shenyang, China"},{"name":"Department of Life Sciences and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongguo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, General Hospital of Northern Theater Command (Teaching Hospital of Dalian Medical University), No. 83 Wenhua Road, Shenyang 110840, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, General Hospital of Northern Theater Command (Teaching Hospital of Dalian Medical University), No. 83 Wenhua Road, Shenyang 110840, China"},{"name":"Postgraduate College, Dalian Medical University, Dalian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9448-6739","authenticated-orcid":false,"given":"Xingshun","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, General Hospital of Northern Theater Command (Teaching Hospital of Dalian Medical University), No. 83 Wenhua Road, Shenyang 110840, China"},{"name":"Postgraduate College, Dalian Medical University, Dalian, China"},{"name":"Department of Life Sciences and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2211807"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00431-8"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.12.022"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S308572"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/516077"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i18.5461"},{"key":"e_1_3_4_8_2","article-title":"GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression","volume":"12","author":"Wu Y","year":"2021","unstructured":"Wu Y, Murray GK, Byrne EM, et al. 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