{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T08:08:59Z","timestamp":1779091739814,"version":"3.51.4"},"reference-count":48,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The impact of human leukocyte antigen (HLA) histocompatibility on graft survival is well established in kidney and haematopoietic stem cell transplantation; however, its role in liver transplantation (LT) remains uncertain. Prior studies have reported inconsistent associations between HLA mismatching and LT graft outcomes. Given emerging evidence linking HLA mismatch to post-transplant complications, this relationship warrants reassessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To investigate the effect of HLA Class I (A, B, C) and Class II (DRB1, DQA, DQB) mismatching on LT graft survival in a single-centre retrospective analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A retrospective, single-centre cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>610 patients who underwent their first deceased donor LT between January 2010 and March 2021 were included. The primary outcome was graft failure. Donor and recipient HLA typing was available at HLA-A, HLA-B and HLA-DRB1 loci in 610 patients, HLA-C in 38 patients, HLA-DQA in 63 patients and HLA-DQB in 63 patients. Graft survival was assessed using Kaplan\u2013Meier analysis and predictors identified using Cox regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      HLA-C mismatching was associated with reduced graft survival on Kaplan\u2013Meier analysis (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.02); however, this was based on a small subgroup (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200938), and the univariate Cox estimate was imprecise (HR 9.24, 95% CI 1.01\u201383.48,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.047). HLA-DRB1 mismatching was associated with improved graft survival (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.047) and reduced graft failure risk on multivariate Cox regression (aHR 0.34, 95% CI 0.14\u20130.87,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.02), although limited by the small number of matched transplants (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20099). There was no association between mismatches at other loci and graft survival. Hepatic artery thrombosis worsened graft survival (aHR 3.42, 95% CI 2.44\u20134.80,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) but was not associated with HLA mismatch.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These results suggest that the effect of HLA histocompatibility in LT may be locus-specific. Associations were observed for differential graft outcomes at the HLA-C and HLA-DRB1 loci; however, given the small sample sizes and imprecision of estimates, these findings should be considered hypothesis-generating and require validation in larger prospective cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17562848261447157","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T07:31:38Z","timestamp":1778830298000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of human leukocyte antigen histocompatibility and its impact on liver transplant graft outcomes"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7802-2803","authenticated-orcid":false,"given":"Dorothy","family":"Liu","sequence":"first","affiliation":[{"name":"Victorian Liver Transplant Unit, Austin Health, 145 Studley Road, Heidelberg, VIC 3084, Australia"},{"name":"Australian Centre for Transplantation Excellence and Research (ACTER), Austin Health, Melbourne, VIC, Australia"},{"name":"Department of Medicine, The University of Melbourne, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Collins","sequence":"additional","affiliation":[{"name":"Victorian Liver Transplant Unit, Austin Health, Melbourne, VIC, Australia"},{"name":"Department of Gastroenterology, Barwon Health, Geelong, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos V.","family":"Perini","sequence":"additional","affiliation":[{"name":"Victorian Liver Transplant Unit, Austin Health, Melbourne, VIC, Australia"},{"name":"Australian Centre for Transplantation Excellence and Research (ACTER), Austin Health, Melbourne, VIC, Australia"},{"name":"Department of Surgery, The University of Melbourne, Melbourne, VIC, 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