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Pouchitis, the most common complication after this surgery, substantially reduces patients\u2019 quality of life (QoL). In chronic pouchitis, antibiotic treatment often proves ineffective. Fecal microbiota transplantation (FMT) has emerged as a potential treatment for chronic pouchitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To determine the effect of FMT on QoL in patients with chronic pouchitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>An exploratory post hoc analysis of data from the MicroPouch trial. A double-blinded, placebo-controlled study comprising a 4-week intervention period and 12-month follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>Thirty patients with chronic pouchitis were randomized 1:1 to receive either FMT or placebo. Treatment was administered by enema once daily for 2\u2009weeks, then every other day for the following 2\u2009weeks. QoL was assessed using three questionnaires\u2014the Short Inflammatory Bowel Disease Questionnaire (SIBDQ), the Pouch Dysfunction Score (PDS), and the 36-item Short Form Questionnaire (SF-36)\u2014at baseline and at subsequent follow-ups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      At the 30-day follow-up, FMT-treated patients showed a significant decrease in QoL from baseline, measured by the SIBDQ (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.03). Within the FMT group, the PDS did not change significantly from baseline to day 30 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.36). The placebo group reported higher SF-36 QoL scores at both baseline and day 30 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.02), although neither group showed significant within-group changes over time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In patients with chronic pouchitis, FMT may temporarily worsen symptoms and reduce QoL, as indicated by three QoL questionnaires showing no improvement or poorer outcomes versus placebo.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Trial registration<\/jats:italic>\n                        :\n                      <\/jats:bold>\n                      The study is registered at ClinicalTrials.gov (Trial number NCT04100291), date: 12 September 2019.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17562848261452497","type":"journal-article","created":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T08:46:03Z","timestamp":1780217163000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The effect of fecal microbiota transplantation on quality of life in patients with chronic pouchitis: a post hoc analysis of the MicroPouch trial"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0450-8317","authenticated-orcid":false,"given":"Sarah S\u00f8gaard","family":"Jakobsen","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery, Aalborg University Hospital, Hospitalsbyen 1, Gistrup 9260, Denmark"},{"name":"Department of Clinical Medicine, Aalborg University, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina Just","family":"Kousgaard","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Aalborg University Hospital, Gistrup, Denmark"},{"name":"Department of Clinical Medicine, Aalborg University, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2085-8496","authenticated-orcid":false,"given":"Frederik","family":"Cold","sequence":"additional","affiliation":[{"name":"Gastrounit, Medical Section, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7518-4252","authenticated-orcid":false,"given":"Sofie Ingdam","family":"Halkj\u00e6r","sequence":"additional","affiliation":[{"name":"Gastrounit, Medical Section, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas Munk","family":"Petersen","sequence":"additional","affiliation":[{"name":"Gastrounit, Medical Section, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark"},{"name":"Department of Clinical Microbiology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Kjeldsen","sequence":"additional","affiliation":[{"name":"Department of Medical Gastrointestinal Diseases, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane M\u00f8ller","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Medical Gastrointestinal Diseases, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Thorlacius-Ussing","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Aalborg University Hospital, Gistrup, Denmark"},{"name":"Department of Clinical Medicine, Aalborg University, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,31]]},"reference":[{"key":"e_1_3_5_2_2","unstructured":"Golubnitschaja O Boyko N Parini P et al.; Editor S. 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