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It has gained significant attention for its role in managing gut dysbiosis-associated disorders, particularly hepatic diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      This systematic review evaluated the therapeutic efficacy and clinical potential of FMT in the management of liver-related conditions, including recurrent\n                      <jats:italic toggle=\"yes\">Clostridium difficile<\/jats:italic>\n                      infection (CDI), non-alcoholic fatty liver disease, liver cirrhosis, and hepatic encephalopathy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A systematic review of existing literature was conducted to assess the clinical outcomes, mechanisms, and challenges associated with FMT in hepatic disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data sources and methods:<\/jats:title>\n                    <jats:p>Relevant studies were identified from peer-reviewed scientific databases, focusing on clinical trials, observational studies, and experimental research investigating the role of FMT in gut dysbiosis and liver disease. Data were analyzed to evaluate efficacy, underlying mechanisms, and safety considerations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>FMT demonstrated high efficacy in recurrent CDI, with cure rates exceeding 80%\u201390%. In hepatic disorders, FMT was associated with improved microbial diversity, enhanced gut barrier integrity, and reduced systemic inflammation, contributing to better liver function and clinical outcomes. However, variability in donor selection, potential safety risks, and regulatory limitations remain significant challenges.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>FMT represents a promising therapeutic strategy in hepatology, underscoring the critical role of the gut\u2013liver axis. Advances such as synthetic microbiota and personalized microbiome-based therapies may further optimize its safety and efficacy, paving the way for innovative, microbiome-centered interventions in liver disease management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17562848261452504","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T11:27:06Z","timestamp":1779967626000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Fecal microbiota transplant and its usefulness in hepatic disorders: a systematic review"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8569-988X","authenticated-orcid":false,"given":"Arun Kumar","family":"Mishra","sequence":"first","affiliation":[{"name":"Sahu Onkar Saran School of Pharmacy, Faculty of Pharmacy, IFTM University, Moradabad 244102, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrita","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of B.Pharm (Ayurveda), School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash","family":"Vikal","sequence":"additional","affiliation":[{"name":"Sahu Onkar Saran School of Pharmacy, Faculty of Pharmacy, IFTM University, Moradabad 244102, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harpreet","family":"Singh","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Faculty of Pharmacy, IFTM University, Moradabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Y Thajudeen","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyas","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Jazan University, Jazan, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Muqtader","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X15607414"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/20503121241257486"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens13020118"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2020.100642"},{"key":"e_1_3_4_6_2","first-page":"279","article-title":"Efficacy-to-effectiveness clinical trials","volume":"129","author":"Selker HP","year":"2018","unstructured":"Selker HP, Gorman S, Kaitin KI. 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