{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:27:58Z","timestamp":1787239678255,"version":"build-2736575974"},"reference-count":51,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100012131","name":"department of science and technology of liaoning province","doi-asserted-by":"publisher","award":["2023JH2\/101700099"],"award-info":[{"award-number":["2023JH2\/101700099"]}],"id":[{"id":"10.13039\/501100012131","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Independent Research Funding of General Hospital of Northern Theater Command","award":["ZZKY2024018"],"award-info":[{"award-number":["ZZKY2024018"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      The association of\n                      <jats:italic toggle=\"yes\">Helicobacter pylori<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      ) infection with non-alcoholic fatty liver disease (NAFLD) remains controversial. Additionally, its associations with metabolic dysfunction-associated fatty liver disease (MAFLD), metabolic dysfunction-associated steatotic liver disease (MASLD), and Chinese MAFLD using the most recent diagnostic criteria were unclear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      To analyze the associations of\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      infection with NAFLD, MAFLD, MASLD, and Chinese MAFLD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Cross-sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This study screened 1172 inpatients who underwent both\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      test and liver computed tomography or ultrasound examination between June 2020 and May 2024. Multivariate Logistic regression analyses were performed to evaluate the associations of\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      infection with the severity of hepatic steatosis and risk of hepatic fibrosis. Adjusted odds ratios (aORs) with 95% confidence intervals (CIs) were calculated after adjusting for gender, hypertension, hyperlipidemia, body mass index (BMI), fasting plasma glucose (FPG), and high-sensitivity C-reactive protein (HsCRP) in NAFLD analyses; age, gender, drinking, hypertension, diabetes, hyperlipidemia, BMI, and HsCRP in MAFLD analyses; and gender, drinking, hypertension, hyperlipidemia, BMI, FPG, and HsCRP in MASLD and Chinese MAFLD analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Overall, 875, 982, 869, and 869 patients were included in NAFLD, MAFLD, MASLD, and Chinese MAFLD analyses, respectively. In NAFLD, MAFLD, MASLD, and Chinese MAFLD analyses, 257, 302, 257, and 257 patients had\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      infection, respectively.\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      infection was independently associated with severe hepatic steatosis in NAFLD (aOR\u2009=\u20093.956; 95% CI\u2009=\u20091.171\u201313.359,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.027), MAFLD (aOR\u2009=\u20093.730; 95% CI\u2009=\u20091.083\u201312.850,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.037), and MASLD (aOR\u2009=\u20093.962; 95% CI\u2009=\u20091.158\u201313.557,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.028) analyses, but not Chinese MAFLD analyses. However,\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      infection was not independently associated with the risk of hepatic fibrosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      infection may increase the severity of NAFLD, MAFLD, and MASLD, but not the risk of liver fibrosis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17562848261465720","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:18:54Z","timestamp":1785496734000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations of\n                    <i>Helicobacter pylori<\/i>\n           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Medical University), Shenyang, China"},{"name":"Postgraduate College, Dalian Medical University, Dalian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Chen","sequence":"additional","affiliation":[{"name":"Anju District People\u2019s Hospital of Sui Ning, Suining, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongguo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenyang, Liaoning Province 110840, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenyang, Liaoning Province 110840, 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