{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:18:51Z","timestamp":1786115931956,"version":"build-2736575974"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>The International Organization for the Study of Inflammatory Bowel Disease (IOIBD) is an international scientific organization that has shaped the framework for inflammatory bowel disease (IBD) research, clinical management strategy, therapeutic development, and clinical trial methodology for more than four decades. Formally constituted in April 1981 in Lyon, France, IOIBD was created to address fundamental barriers to scientific and clinical progress in IBD, including inconsistent definitions of disease activity and outcomes across studies and countries. Since the establishment of the IOIBD Foundation for Research and Education in 1997, IOIBD has combined a highly engaged global membership of experts with structured governance, continuously active thematic clusters, and an annual rotating international meeting to deliver consensus frameworks and collaborative initiatives that translate directly to clinical practice and regulatory and translational science. Key outputs include studies of global epidemiology of IBD, the Selecting Therapeutic Targets in IBD (Selecting Therapeutic Targets in Inflammatory Bowel Disease, STRIDE) treat-to-target programs; the SPIRIT consensus initiative addressing long-term disease impact and endpoints for disease-modification trials; validated approaches to capturing disability and patient-reported outcomes; consensus guidance on nutrition and diet as modifiable and potentially disease-modifying factors; recommendations to optimize IBD clinical trial design and endpoints; reclassification of IBD initiative; rapid international guidance during the COVID-19 pandemic; and educational initiatives including topic-focused satellite symposia, the Helmsley\u2013IOIBD Clinical Experience Exchange Program, and the Empowering Women in IBD Leadership Program (EMPOWHER). This manuscript reviews IOIBD\u2019s history, operational model, selected scientific contributions, educational mission, and evolving strategy as the field moves toward precision medicine, globalization of care, and data-intensive approaches, including artificial intelligence.<\/jats:p>","DOI":"10.1177\/17562848261470923","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T06:26:27Z","timestamp":1785738387000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["IOIBD: the International Organization for the Study of Inflammatory Bowel Disease"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8005-7706","authenticated-orcid":false,"given":"Iris","family":"Dotan","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Rabin Medical Center, 39 Jabotinsky St, Petah Tikva 4941492, Israel"},{"name":"Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marla C.","family":"Dubinsky","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, IBD Centre, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey A.","family":"Siegel","sequence":"additional","affiliation":[{"name":"Dartmouth Hitchcock Medical Center, Center for Digestive Health, Lebanon, NH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Lindsay","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Barts Health NHS Trust, The Royal London Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dermot","family":"McGovern","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Medical Center, F. Widjaja Inflammatory Bowel Institute, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Allez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, McGill University Health Centre, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4r","family":"Myrelid","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden"},{"name":"Clinical Department of Surgery, Region \u00d6sterg\u00f6tland, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Lewis","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of Pennsylvania, Moorestown, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5762-5042","authenticated-orcid":false,"given":"Bruce E.","family":"Sands","sequence":"additional","affiliation":[{"name":"Dr. Henry D. Janowitz Division of GE, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2536-6618","authenticated-orcid":false,"given":"Laurent","family":"Peyrin-Biroulet","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nancy University, Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Danese","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital San Raffaele, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1577-0118","authenticated-orcid":false,"given":"Vineet","family":"Ahuja","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2719-0556","authenticated-orcid":false,"given":"Gilaad G.","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marischka","family":"Konings","sequence":"additional","affiliation":[{"name":"Congress Agency, MK Producties BV, Baarn, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Gearry","sequence":"additional","affiliation":[{"name":"University of Otago, Christchurch, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6850-4454","authenticated-orcid":false,"given":"Siew C.","family":"Ng","sequence":"additional","affiliation":[{"name":"Microbiota I-Center (MagIC), Hong Kong, China"},{"name":"Department of Medicine and Therapeutics, State Key Laboratory of Digestive Diseases, Li Ka Shing Institute of Health Sciences, New Cornerstone Science Laboratory, The Chinese University of Hong Kong, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vipul","family":"Jairath","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Western University, London, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Magro","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, S\u00e3o Jo\u00e3o University Hospital Center, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Silverberg","sequence":"additional","affiliation":[{"name":"Department of Medicine, Sinai Health System, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Turner","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Shaare Zedek Medical Center, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria T.","family":"Abreu","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Medical Center, F. Widjaja Inflammatory Bowel Institute, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailsa","family":"Hart","sequence":"additional","affiliation":[{"name":"St. Mark\u2019s Hospital and Imperial College, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Dignass","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Agaplesion Markus Hospital, Goethe University, Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Rubin","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the International Organization for the Study of Inflammatory Bowel Diseases (IOIBD)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,2]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-025-01097-1"},{"key":"e_1_3_4_3_2","unstructured":"IOIBD\u2014International Organization for the Study of Inflammatory Bowel Disease https:\/\/ioibd.org\/"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.233"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.12.031"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.10.065"},{"key":"e_1_3_4_7_2","first-page":"262","article-title":"Development and validation of a disability index for inflammatory bowel disease","volume":"66","author":"D\u2019Haens G","year":"2017","unstructured":"D\u2019Haens G, Kelly O, Battat R, et al. Development and validation of a disability index for inflammatory bowel disease. Gut 2017; 66: 262\u2013268.","journal-title":"Gut"},{"key":"e_1_3_4_8_2","first-page":"1","article-title":"Dietary guidance from the international organization for the study of inflammatory bowel disease","volume":"14","author":"Levine A","year":"2020","unstructured":"Levine A, Rhodes JM, Lindsay JO, et al. Dietary guidance from the international organization for the study of inflammatory bowel disease. J Crohns Colitis 2020; 14: 1\u201317.","journal-title":"J Crohns Colitis"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv067"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00154-1"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12547"},{"key":"e_1_3_4_12_2","first-page":"1","article-title":"Evolving concepts in clinical trial design for inflammatory bowel disease","volume":"13","author":"Sands BE","year":"2020","unstructured":"Sands BE, Peyrin-Biroulet L, Loftus EVJr, et al. Evolving concepts in clinical trial design for inflammatory bowel disease. Ther Adv Gastroenterol 2020; 13: 1\u201314.","journal-title":"Ther Adv Gastroenterol"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjae097"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjad205"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-023-01944-2"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08940-0"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-025-01063-x"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2025.08.017"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(25)00299-7"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.04.002"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-324000"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjaa147"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjag007"}],"container-title":["Therapeutic Advances in Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562848261470923","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17562848261470923","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562848261470923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T06:18:05Z","timestamp":1785997085000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17562848261470923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":22,"alternative-id":["10.1177\/17562848261470923"],"URL":"https:\/\/doi.org\/10.1177\/17562848261470923","relation":{},"ISSN":["1756-2848","1756-2848"],"issn-type":[{"value":"1756-2848","type":"print"},{"value":"1756-2848","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"article-number":"17562848261470923"}}