{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:18:51Z","timestamp":1786115931989,"version":"build-2736575974"},"reference-count":12,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"\n Background<\/jats:title>\n \n Impaired diffusing capacity of the lung for carbon monoxide (DL\n CO<\/jats:sub>\n ) has been frequently described among patients with inflammatory bowel diseases, but longitudinal data of DL\n CO<\/jats:sub>\n impairment and its association with IBD activity remain unclear.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n To describe the longitudinal report of prevalence and clinical characteristics of chronic DL\n CO<\/jats:sub>\n impairment among patients with IBD reporting respiratory symptoms.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n We conducted a prospective single-center study including consecutive patients with confirmed IBD and respiratory symptoms.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Patients underwent longitudinal evaluation with chest CT scans and pulmonary function tests.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 75 patients with DL\n CO<\/jats:sub>\n measurements, 12 (16%) showed persistently reduced DL\n CO<\/jats:sub>\n over a median follow-up of 26.9 [IQR 24.9\u201330.6] months. Median DL\n CO<\/jats:sub>\n was 63.4% of predicted value. All patients had mild or inactive IBD and were on biologics. Imaging abnormalities were mild and did not explain the DL\n CO<\/jats:sub>\n reduction.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Chronic DL\n CO<\/jats:sub>\n impairment was observed in 16.0% of IBD patients and no obvious association with clinically active IBD was observed in this selected symptomatic cohort.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/17562848261475935","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T13:24:17Z","timestamp":1785763457000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pulmonary diffusion abnormalities in patients with inflammatory bowel disease: A longitudinal study"],"prefix":"10.1177","volume":"19","author":[{"given":"Hugo","family":"Maisonneuve","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Lorraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedicte","family":"Caron","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Guillaumot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Poussel","sequence":"additional","affiliation":[{"name":"University Centre of Sports Medicine and Adapted Physical Activity"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sorel","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Chabot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Ribeiro Baptista","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine"},{"name":"Universit\u00e9 de Lorraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2536-6618","authenticated-orcid":false,"given":"Laurent","family":"Peyrin-Biroulet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Chaouat","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine"},{"name":"Universit\u00e9 de Lorraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9304-1359","authenticated-orcid":false,"given":"Simon","family":"Valentin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine"},{"name":"Universit\u00e9 de Lorraine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv213"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izac062"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(98)90301-8"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.4318\/tjg.2011.0215"},{"issue":"4","key":"e_1_3_8_6_2","first-page":"25","article-title":"Role of pulmonary function testing in inflammatory bowel diseases (Review)","volume":"2","author":"Georgakopoulou VE","year":"2022","unstructured":"Georgakopoulou VE, Tarantinos K, Papalexis P, et al. Role of pulmonary function testing in inflammatory bowel diseases (Review). Med Int (Lond) 2022; 2(4): 25. https:\/\/doi.org\/10.3892\/mi.2022.50","journal-title":"Med Int (Lond)"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i39.4952"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200310000-00006"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001989"},{"issue":"203","key":"e_1_3_8_11_2","first-page":"241","article-title":"Pulmonary function abnormalities in patients with inflammatory bowel disease","volume":"51","author":"Heatley RV","year":"1982","unstructured":"Heatley RV, Thomas P, Prokipchuk EJ, et al. Pulmonary function abnormalities in patients with inflammatory bowel disease. Q J Med 1982; 51(203): 241\u2013250.","journal-title":"Q J Med"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05473.x"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker289"}],"container-title":["Therapeutic Advances in Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562848261475935","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17562848261475935","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562848261475935","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T06:18:17Z","timestamp":1785997097000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17562848261475935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":12,"alternative-id":["10.1177\/17562848261475935"],"URL":"https:\/\/doi.org\/10.1177\/17562848261475935","relation":{},"ISSN":["1756-2848","1756-2848"],"issn-type":[{"value":"1756-2848","type":"print"},{"value":"1756-2848","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"article-number":"17562848261475935"}}