{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:12:52Z","timestamp":1788667972224,"version":"build-2803163510"},"reference-count":45,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Clinical Medicine + X Research Project of the Affiliated Hospital of Qingdao University in 2024","award":["QDFY+X2024212"],"award-info":[{"award-number":["QDFY+X2024212"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The relationship between nutritional indices and treatment response in ulcerative colitis (UC) remains poorly characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the discriminatory ability of Geriatric Nutritional Risk Index (GNRI), Malnutrition Universal Screening Tool (MUST), and Prognostic Nutritional Index (PNI) in evaluating the clinical efficacy of vedolizumab (VDZ) in patients with moderate-to-severe UC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A retrospective multicenter study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study enrolled moderate-to-severe UC patients receiving VDZ at three centers in northern China from 2021 to 2025. The relationship between baseline nutritional indices and clinical remission, alongside conventional biomarkers, was analyzed. Discriminatory performance was evaluated using receiver operating characteristic curves and area under the curve (AUC) analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 184 patients were included. At week 14, multivariable logistic regression identified GNRI, PNI and MUST as factors significantly associated with clinical remission. GNRI showed the strongest correlation with clinical remission (r=0.340,\n                      <jats:italic toggle=\"yes\">p&lt;<\/jats:italic>\n                      0.001), followed by HGB (r=0.316,\n                      <jats:italic toggle=\"yes\">p&lt;<\/jats:italic>\n                      0.001), PNI (r=0.308,\n                      <jats:italic toggle=\"yes\">p&lt;<\/jats:italic>\n                      0.001), PLR (r=-0.271,\n                      <jats:italic toggle=\"yes\">p&lt;<\/jats:italic>\n                      0.001), MUST (r=-0.216,\n                      <jats:italic toggle=\"yes\">p=<\/jats:italic>\n                      0.003), and NLR (r=-0.163,\n                      <jats:italic toggle=\"yes\">p=<\/jats:italic>\n                      0.027). GNRI had the highest AUC (0.697), followed by HGB (0.683), PNI (0.678), Alb (0.660), PLR (0.657) and MUST (0.614). GNRI exhibited significantly greater discriminatory ability for 14-week clinical remission than Alb (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      =0.018) and MUST (\n                      <jats:italic toggle=\"yes\">p=<\/jats:italic>\n                      0.041). No significant differences in diagnostic accuracy were found between GNRI, HGB, PNI, PLR, and NLR (\n                      <jats:italic toggle=\"yes\">p&gt;<\/jats:italic>\n                      0.05). At week 30 and 54, multivariate analysis showed that only baseline HGB remained independently associated with remission.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with lower nutritional risk\u2014as reflected by higher GNRI and PNI scores, alongside lower MUST scores-were significantly more likely to achieve clinical remission at week 14.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17562848261486841","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:42:21Z","timestamp":1788529341000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of nutritional indices with early clinical remission in patients with moderate-to-severe ulcerative colitis treated with vedolizumab"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4296-1404","authenticated-orcid":false,"given":"Hao","family":"Zhang","sequence":"first","affiliation":[{"name":"The Affiliated Hospital of Qingdao University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wu","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Wang","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congcong","family":"Min","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin","family":"Meng","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Liu","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Mao","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8428-0577","authenticated-orcid":false,"given":"Yonghong","family":"Xu","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Jin","sequence":"additional","affiliation":[{"name":"People\u2019s Hospital of Rizhao"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baihui","family":"Wang","sequence":"additional","affiliation":[{"name":"Qilu Hospital of Shandong University (Qingdao)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Han","sequence":"additional","affiliation":[{"name":"Case Western Reserve University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailing","family":"Liu","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueli","family":"Ding","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32448-0"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17389"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu16121826"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjw092"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-018-1480-0"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2024.10.001"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjad043"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.02.010"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-025-01601-6"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/2050640620965106"},{"issue":"3","key":"e_1_3_7_12_2","first-page":"407","article-title":"Predictors of the efficacy of vedolizumab in patients with ulcerative colitis","volume":"86","author":"Kajikawa G","year":"2024","unstructured":"Kajikawa G, Sawada T, Nakamura M, et al. 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