{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T22:08:28Z","timestamp":1768082908301,"version":"3.49.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2009,8,12]],"date-time":"2009-08-12T00:00:00Z","timestamp":1250035200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Adv Neurol Disord"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:p>Although zonisamide was previously only used to treat epilepsy, recently more applications have been forthcoming. Due to a good side effect profile, a lower frequency of interactions and a more comfortable posology, there are several studies regarding its uses in other pathologies such as migraine, neuropathic pain, essential tremor and various psychiatric diseases. A multicentered, randomized, double-blind, placebo-controlled study conducted in Japan suggested that zonisamide, as an add-on treatment, has efficacy in treating motor symptoms in patients with Parkinson\u2019s disease. In addition, other studies support the utility of zonisamide in other symptoms of this disease. The therapeutic doses of zonisamide for the treatment of Parkinson\u2019s disease are considerably lower than those for the treatment of epilepsy. This antiepileptic drug has been used in Japan for more than 15 years and so it is expected that it will be safe and well tolerated in patients with Parkinson\u2019s disease. However, the pharmacological mechanisms of the antiparkinsonian actions of zonisamide remain unclear and more basic investigation is warranted. The aim of this paper is to review the structure, mechanisms of action, pharmacokinetics and antiparkinsonian action of zonisamide.<\/jats:p>","DOI":"10.1177\/1756285609338501","type":"journal-article","created":{"date-parts":[[2009,8,13]],"date-time":"2009-08-13T01:12:16Z","timestamp":1250125936000},"page":"313-317","source":"Crossref","is-referenced-by-count":33,"title":["Review: A review of the use of zonisamide in Parkinson\u2019s disease"],"prefix":"10.1177","volume":"2","author":[{"given":"Pedro Emilio","family":"Bermejo","sequence":"first","affiliation":[{"name":"Sanatorio Nuestra Se\u00f1ora del Rosario - Hospital Sanitas La Zarzuela, Madrid, Spain,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Buenaventura","family":"Anciones","sequence":"additional","affiliation":[{"name":"Sanatorio Nuestra Se\u00f1ora del Rosario - Hospital Sanitas La Zarzuela, Madrid, 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