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LCM shows comparable efficacy with other antiepileptic drugs (AEDs) licensed in the last decade: in three randomized placebo-controlled trials, significant median seizure reduction rates of 35.2% for 200 mg\/day, 36.4\u201339% for 400 mg\/day and 37.8\u201340% for 600 mg\/day were reported. Likewise, 50% responder rates were 38.3\u201341.1% for 400 mg\/day and 38.1\u201341.2% for 600 mg\/day. Similar rates were reported in post-marketing studies. The main adverse events (AEs) are dizziness, abnormal vision, diplopia and ataxia. Overall, LCM is well tolerated and has no clinically-relevant drug\u2013drug interactions. Due to the drug\u2019s intravenous availability, its use in status epilepticus (SE) is increasing, and the available data are promising. <\/jats:p>","DOI":"10.1177\/1756285616675777","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T12:33:15Z","timestamp":1478781195000},"page":"103-126","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["The efficacy of lacosamide as monotherapy and adjunctive therapy in focal epilepsy and its use in status epilepticus: clinical trial evidence and experience"],"prefix":"10.1177","volume":"10","author":[{"given":"Sebastian","family":"Bauer","sequence":"first","affiliation":[{"name":"Epilepsy Center Frankfurt Rhine-Main and Department of Neurology, Goethe-University, Frankfurt am Main, Germany Epilepsy Center Hessen and Department of Neurology, Philipps-University, Marburg, 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