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Biopsy of the lesion confirmed the demyelinating origin and brain magnetic resonance imaging showed additional lesions demonstrative of dissemination in space. Immunomodulatory therapy with glatiramer acetate (GA) was started after having a second relapse 2 months later. Shortly after initiation, the patient developed acute hepatitis. Liver function tests returned to normal values 5 months after discontinuation and the patient was diagnosed with drug-induced liver injury (DILI) associated with GA. A literature review identified 11 previous cases of GA-related liver injury associated with two specific mechanisms: DILI (seven cases) and autoimmune hepatitis (four cases). Despite the fact that GA hepatic toxicity is uncommon and laboratory monitoring is not required during GA therapy, it should be considered at least in some special conditions such as comorbidities and previous history of DILI associated with other drugs. <\/jats:p>","DOI":"10.1177\/1756285617722352","type":"journal-article","created":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T13:13:40Z","timestamp":1501074820000},"page":"367-372","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Liver injury and glatiramer acetate, an uncommon association: case report and literature review"],"prefix":"10.1177","volume":"10","author":[{"given":"Javier","family":"Almeida","sequence":"first","affiliation":[{"name":"Neurology Department, Cruces University Hospital, Barakaldo, Bizkaia, Spain and Neuroimmunology Program, Service of Neurology, Hospital Clinic, Institut d\u2019Investigacions Biom\u00e8diques August Pi i 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