{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T21:15:02Z","timestamp":1768079702879,"version":"3.49.0"},"reference-count":19,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Neurol Disord"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Neurosarcoidosis occurs in about 5\u201315% of patients with sarcoidosis. Therapy with corticosteroids is generally accepted as the first-line medication, followed by various immunomodulating and cytotoxic agents or combined therapy. However, some patients show an unsatisfactory outcome or have adverse events and require novel treatment strategies. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> We describe three patients with systemic sarcoidosis and central nervous system involvement who received CD20-targeted B-cell depletion with rituximab. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Treatment with rituximab was well tolerated and followed by marked remission in patients nonresponsive to other immunosuppressive agents. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Rituximab may be used for patients with neurosarcoidosis who are nonresponsive to established treatment regimes. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1756286418805732","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T13:35:08Z","timestamp":1540560908000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":39,"title":["Successful therapy with rituximab in three patients with probable neurosarcoidosis"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0815-9820","authenticated-orcid":false,"given":"Samis","family":"Zella","sequence":"first","affiliation":[{"name":"Department of Neurology at St. Josef Hospital, Medical Faculty of the Ruhr-University Bochum, Gudrunstr. 56, D-44791 Bochum, Germany Department of Neurology at Katholische Kliniken Ruhrhalbinsel Essen, Heidbergweg 22-24, D-45257 Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janina","family":"Kneiphof","sequence":"additional","affiliation":[{"name":"Department of 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